Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage : Kinetic profile, relationship to interleukin 6 and infarct size.

Abstract

BACKGROUND:

The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size.

METHODS:

PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI).

RESULTS:

PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0-72 hours). In a linear mixed model, PTX3 predicted IL-6 (p < 0.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI (ρ = 0.23, p = 0.006).

CONCLUSIONS:

PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI.

• Authors: Noreen Butt, L K Bache-Mathiesen, A Ushakova, J E Nordrehaug, S E Jensen, P S Munk, N Danchin, J L Dubois-Rande, H S Hansen, F Paganelli, P Le Corvoisier, H Firat, D Erlinge, D Atar, A I Larsen
• Journal: European heart journal. Acute cardiovascular care (Eur Heart J Acute Cardiovasc Care) Vol. 9 Issue 4 Pg. 302-312 (Jun 2020) ISSN: 2048-8734 [Electronic] England
• PMID: 32403934 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Interleukin-6
• Serum Amyloid P-Component
• Troponin I
• Troponin T
• PTX3 protein
• C-Reactive Protein

Topics

• Aged
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Female
• Follow-Up Studies
• Humans
• Interleukin-6 (blood)
• Male
• Middle Aged
• Myocardium (metabolism)
• Percutaneous Coronary Intervention
• Retrospective Studies
• ST Elevation Myocardial Infarction (blood, diagnosis, surgery)
• Serum Amyloid P-Component (metabolism)
• Severity of Illness Index
• Troponin I (blood)
• Troponin T (blood)