PTX3 protein

pentaxin-related protein made up of 381 amino acid residues; a tumor necrosis factor (TNF)- & IL-1-inducible protein, member of the pentaxin family of acute phase proteins; amino acid sequence given in first source; pentraxin is sometimes misspelled as pentaxin; do not confuse with Pitx3, a pituitary homeobox protein; RefSeq NM_002852 (human); see also neuronal pentraxin

Also Known As:

Networked: 660 relevant articles (9 outcomes, 95 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mantovani, Alberto: 46 articles (11/2022 - 02/2003)
2.	Bottazzi, Barbara: 25 articles (09/2021 - 02/2003)
3.	Garlanda, Cecilia: 22 articles (11/2022 - 05/2006)
4.	Presta, Marco: 11 articles (05/2021 - 09/2005)
5.	Larsson, Anders: 7 articles (11/2022 - 10/2011)
6.	Ronca, Roberto: 7 articles (05/2021 - 06/2013)
7.	Kodama, Tatsuhiko: 7 articles (06/2012 - 01/2007)
8.	Huang, Chun-Jung: 6 articles (06/2021 - 03/2014)
9.	Slusher, Aaron L: 6 articles (06/2021 - 02/2015)
10.	Giacomini, Arianna: 6 articles (05/2021 - 06/2013)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule (PRM) involved in resistance to selected microbial agents and in regulation of inflammation. " 12/01/2022 - "Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role." 06/15/2022 - "The long pentraxin 3 (PTX3) is quickly released directly at inflammation sites by many immune cell types. " 01/15/2022 - "Moreover, RNA-sequence and validation experiments verified that Pentraxin 3 (PTX3), an important mediator in the regulation of inflammation, was elevated both in vivo and in vitro induced by WC-Co. " 01/01/2022 - "(ii) LDS patients had increased levels of pentraxin 3 (PTX3), reflecting systemic inflammation. "
2.	Non-alcoholic Fatty Liver Disease 01/01/2021 - "Pentraxin 3 and the TyG Index as Two Novel Markers to Diagnose NAFLD in Children." 01/01/2016 - "It was suggested that serum pentraxin 3 (PTX3) levels could differentiate obese children with nonalcoholic steatohepatitis (NASH) from those with simple steatosis. " 01/01/2016 - "Serum Pentraxin 3 Fragment as a Noninvasive Marker of Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents." 11/01/2015 - "Plasma Pentraxin 3 Differentiates Nonalcoholic Steatohepatitis (NASH) from Non-NASH." 01/01/2016 - "The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. "
3.	Type 2 Diabetes Mellitus (MODY) 01/01/2020 - "Correlates of pentraxin 3 serum concentration in men and women with type 2 diabetes." 07/01/2008 - "In patients with type 2 diabetes, pentraxin 3 was significantly higher than in control subjects. " 01/01/2019 - "Serum pentraxin 3 concentration in patients with type 2 diabetes and nonalcoholic fatty liver disease." 08/26/2014 - "Elevated plasma pentraxin 3 levels are associated with development and progression of diabetic retinopathy in Korean patients with type 2 diabetes mellitus." 01/01/2013 - "Evaluation of the association of plasma pentraxin 3 levels with type 2 diabetes and diabetic nephropathy in a Malay population."
4.	Insulin Resistance 10/09/2012 - "The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention." 04/01/2013 - "Relationship of pentraxin 3 with insulin sensitivity in gestational diabetes." 09/01/2012 - "High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome." 07/01/2016 - "Association of pentraxin 3 with insulin resistance and glucose response following maximal aerobic exercise in obese and normal-mass individuals." 10/01/2014 - "Oral coenzyme Q10 supplementation in patients with nonalcoholic fatty liver disease: effects on serum vaspin, chemerin, pentraxin 3, insulin resistance and oxidative stress."
5.	Left Ventricular Dysfunction 01/01/2023 - "Interestingly, HCC patients often have higher levels of pentraxin 3 (PTX3), and PTX3 inhibition was found to improve left ventricular dysfunction in animal models. " 02/15/2011 - "Pentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction."

Related Drugs and Biologics

1.	Pattern Recognition Receptors
2.	Glucagon-Like Peptide-1 Receptor Agonists
3.	Proteins (Proteins, Gene)
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Glucose (Dextrose)
6.	Complement System Proteins (Complement)
7.	Hyaluronic Acid (Hyaluronan)
8.	Interleukin-4 (Interleukin 4)
9.	C-Reactive Protein
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Renal Dialysis (Hemodialysis)
4.	Stem Cell Transplantation
5.	Hemodiafiltration