Abstract | BACKGROUND: Loss of swallow tail sign (STS) on iron-sensitive magnetic resonance imaging (MRI) has been recognized as an imaging feature in parkinsonism (PS). PURPOSE: MATERIAL AND METHODS: Ninety-nine patients (55 PD, 29 PSP, and 15 MSA) and 47 healthy controls (HC) were prospectively recruited and scanned using quantitative susceptibility mapping (QSM). STS was visually assessed on SMWI derived from QSM. STS scale in the range of 0-4 at participant level was calculated by summing bilateral STS scores (0-2). We used receiver operating characteristic analysis of STS scale for evaluating the diagnostic power of parkinsonism and Spearman's correlation for assessing disease severity. RESULTS: Frequency distribution of STS scale was significantly different in parkinsonism and HC groups, and among PD, PSP, and MSA subgroups. STS scale ≤3 could distinguish parkinsonism from HC with high accuracy (91.78%), PD from HC (91.18%), and MSA from HC (88.71%). STS scale ≤2 could distinguish PSP from HC (96.05%). STS scale = 0 could distinguish PSP from PD (70.24%) and PSP from MSA (72.73%). STS scale was negatively correlated with H-Y stage (P = 0.007, r = -0.359) and duration of disease (P = 0.006, r = -0.367) in PD patients. CONCLUSION:
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Authors | Xueling Liu, Na Wang, Chen Chen, Pu-Yeh Wu, Sirong Piao, Daoying Geng, Yuxin Li |
Journal | Acta radiologica (Stockholm, Sweden : 1987)
(Acta Radiol)
Vol. 62
Issue 2
Pg. 234-242
(Feb 2021)
ISSN: 1600-0455 [Electronic] England |
PMID | 32380911
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Brain
(diagnostic imaging)
- Brain Mapping
(methods)
- Diagnosis, Differential
- Female
- Humans
- Image Interpretation, Computer-Assisted
(methods)
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Multiple System Atrophy
(diagnostic imaging)
- Parkinson Disease
(diagnostic imaging)
- Prospective Studies
- Severity of Illness Index
- Supranuclear Palsy, Progressive
(diagnostic imaging)
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