Abstract | OBJECTIVE: METHODS: RESULTS: DBT significantly reduced the severity of bleomycin-induced pulmonary fibrosis and inflammation as indicated by minimizing the lost of weight, and by lowering the levels of lung index, inflammation score, Ashcroft score, collagen volume fraction (%), HYP, α-SMA, collagen Ⅰ, collagen Ⅲ, TNF-α, IL-6, IL-1β, TGF-β1, Smad3 and PAI-1, consistent with the effect of prednisone. CONCLUSION:
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Authors | Jiepeng Wang, Chaoyi Fang, Shaoxian Wang, Fang Fang, Xinqiao Chu, Na Liu, Chenxi Lu, Shuo Wang, Wei Li |
Journal | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
(J Tradit Chin Med)
Vol. 40
Issue 2
Pg. 236-244
(04 2020)
ISSN: 2589-451X [Electronic] China |
PMID | 32242389
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Plasminogen Activator Inhibitor 1
- Smad3 Protein
- Transforming Growth Factor beta1
- Bleomycin
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Topics |
- Animals
- Bleomycin
(adverse effects)
- Drugs, Chinese Herbal
(administration & dosage)
- Humans
- Male
- Plasminogen Activator Inhibitor 1
(genetics, metabolism)
- Pulmonary Fibrosis
(chemically induced, drug therapy, genetics, metabolism)
- Rats, Sprague-Dawley
- Signal Transduction
(drug effects)
- Smad3 Protein
(genetics, metabolism)
- Transforming Growth Factor beta1
(genetics, metabolism)
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