Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: The associations of obesity with hypoxanthine, xanthine and plasma XOR activity were investigated in 484 participants (men/women: 224/260) of the Tanno-Sobetsu Study. RESULTS: Levels of hypoxanthine, xanthine and plasma XOR activity were significantly higher in men than in women. In 59 participants with hyperuricemia, 11 (men/women: 11/0) participants were being treated with an XOR inhibitor and had a significantly higher level of xanthine, but not hypoxanthine, than that in participants without treatment. In all of the participants, hypoxanthine concentration in smokers was significantly higher than that in non-smokers. Stepwise and multivariate regression analyses showed that body mass index, smoking habit and xanthine were independent predictors of hypoxanthine after adjustment of age, sex and use of antihyperuricemic drugs. Whereas, alanine transaminase, hypoxanthine and plasma XOR activity were independent predictors for xanthine, and alanine transaminase, triglycerides and xanthine were independent predictors for plasma XOR activity. CONCLUSIONS:
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Authors | Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 11
Issue 4
Pg. 878-887
(Jul 2020)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 31916414
(Publication Type: Journal Article)
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Copyright | © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Biomarkers
- Enzyme Inhibitors
- Triglycerides
- Xanthine
- Hypoxanthine
- Xanthine Dehydrogenase
- Alanine Transaminase
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Topics |
- Adipose Tissue
(metabolism)
- Aged
- Alanine Transaminase
(metabolism)
- Biomarkers
(metabolism)
- Body Mass Index
- Enzyme Inhibitors
(pharmacology)
- Female
- Humans
- Hyperuricemia
(metabolism)
- Hypoxanthine
(metabolism)
- Japan
- Liver
(metabolism)
- Male
- Middle Aged
- Obesity
(metabolism)
- Regression Analysis
- Signal Transduction
(physiology)
- Triglycerides
(metabolism)
- Xanthine
(metabolism)
- Xanthine Dehydrogenase
(blood)
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