Soluble E-cadherin is associated with oxidative stress in patients with chronic HBV infection.

Abstract

Mounting evidence indicates that serum soluble E-cadherin (sE-cadherin) serves as an important player in various physiological and pathological processes. However, the crosstalk between serum sE-cadherin and oxidative stress in chronic hepatitis B (CHB) remains to be illustrated. The main purpose of this study is to explore the molecular mechanisms underlying the function of sE-cadherin in CHB virus infection. Levels of serum sE-cadherin, total antioxidant capacity (TAC), glutathione (GSH), superoxide dismutase (SOD), total oxidant activity (TOA), NADPH oxidase 2 (NOX2), and malondialdehyde (MDA), from 51 patients with hepatitis B envelope antigen (HBeAg)-negative CHB, 54 patients with HBeAg-positive CHB, and 109 healthy individuals were detected by enzyme-linked immunosorbent assay. In our study, patients with CHB showed significantly higher serum sE-cadherin levels than healthy individuals (P < .01). Furthermore, we also found that the serum sE-cadherin levels were significantly negatively correlated with TAC, antioxidant enzymes (GSH and SOD) in patients with CHB, and that serum sE-cadherin concentrations were significantly positively correlated with liver enzyme markers (alanine transaminase and aspartate aminotransferase) and oxidative markers (TOA, NOX2, and MDA) in patients with CHB. Therefore, serum sE-cadherin may act as a new candidate biomarker for reflecting inflammation and oxidative stress status in the development and progression of hepatitis B virus infection.

• Authors: Jun Yang, Yuan Xiong, Lijing Zhou, Yong Huang, Weixian Chen, Bo Wang
• Journal: Journal of medical virology (J Med Virol) Vol. 92 Issue 1 Pg. 34-44 (01 2020) ISSN: 1096-9071 [Electronic] United States
• PMID: 31429942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Antigens, CD
• Antioxidants
• CDH1 protein, human
• Cadherins

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antigens, CD (blood)
• Antioxidants (physiology)
• Cadherins (blood)
• Chronic Disease
• Female
• Hepatitis B, Chronic (blood)
• Humans
• Male
• Middle Aged
• Oxidative Stress
• Young Adult