Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial.

Abstract

To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.

• Authors: Ryusei Uchio, Koutarou Muroyama, Chinatsu Okuda-Hanafusa, Kengo Kawasaki, Yoshihiro Yamamoto, Shinji Murosaki
• Journal: Nutrients (Nutrients) Vol. 11 Issue 8 (Aug 07 2019) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 31394768 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Cyclohexanols
• Placebos
• Plant Extracts
• Sesquiterpenes
• bisacurone
• Water
• turmeric extract

Topics

• Aged
• Biomarkers (blood)
• Curcuma (chemistry)
• Cyclohexanols (administration & dosage)
• Double-Blind Method
• Humans
• Hypertension (blood)
• Inflammation (blood)
• Mental Health
• Middle Aged
• Overweight (blood)
• Placebos
• Plant Extracts (pharmacology)
• Prehypertension (blood)
• Sesquiterpenes (administration & dosage)
• Water