Abstract | BACKGROUND: METHODS: RESULTS:
Thalidomide and 3,6'-dithiothalidomide significantly attenuated the severity of l-dopa-induced dyskinesia while not affecting contralateral turning. Moreover, both compounds inhibited the l-dopa-induced microgliosis and excessive tumor necrosis factor-α in the striatum and substantia nigra reticulata, while restoring physiological levels of the anti-inflammatory cytokine interleukin-10. l-Dopa-induced angiogenesis was inhibited in both basal ganglia nuclei, and l-dopa-induced GLUR1 overexpression in the dorsolateral striatum was restored to normal levels. CONCLUSIONS:
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Authors | Laura Boi, Augusta Pisanu, Nigel H Greig, Michael T Scerba, David Tweedie, Giovanna Mulas, Sandro Fenu, Ezio Carboni, Saturnino Spiga, Anna R Carta |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 34
Issue 12
Pg. 1818-1830
(12 2019)
ISSN: 1531-8257 [Electronic] United States |
PMID | 31335998
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 International Parkinson and Movement Disorder Society. |
Chemical References |
- 3,6'-dithiothalidomide
- Angiogenesis Inhibitors
- Antiparkinson Agents
- Cytokines
- Immunologic Factors
- Receptors, AMPA
- Tumor Necrosis Factor-alpha
- Interleukin-10
- Levodopa
- Thalidomide
- Oxidopamine
- glutamate receptor ionotropic, AMPA 1
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Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Animals
- Antiparkinson Agents
(adverse effects)
- Cytokines
(metabolism)
- Dyskinesia, Drug-Induced
(psychology, therapy)
- Immunologic Factors
(therapeutic use)
- Interleukin-10
(metabolism)
- Levodopa
(adverse effects)
- Male
- Neostriatum
(metabolism)
- Oxidopamine
- Parkinson Disease
(complications, drug therapy)
- Rats
- Rats, Sprague-Dawley
- Receptors, AMPA
(metabolism)
- Substantia Nigra
(metabolism)
- Thalidomide
(analogs & derivatives, therapeutic use)
- Tumor Necrosis Factor-alpha
(metabolism)
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