Abstract | BACKGROUND: METHODS: RESULTS: The diabetic cohort had an initial GFR of 25 ± 9 ml/min per 1.73 m2 and a renal function decline of 2.9 ± 3.0 ml/min per 1.73 m2 per year. All complement biomarkers were strongly intercorrelated and associated with biomarker inflammation and fibrosis, proteinuria, and the rate of renal function decline. There was a significant interaction (P = 0.03) between the level of proteinuria and urinary sC5b-9: in individuals with higher levels of urinary MAC, the relationship between proteinuria and the rate of renal function decline was more pronounced than in those with low urinary MAC. Finally, patients with DN had levels of urinary sC5b-9 comparable to autoimmune glomerulonephritis, when stratified by the level of proteinuria. CONCLUSION: Urinary MAC is present in patients with overt DN at levels comparable to autoimmune glomerulonephritis and correlates with the GFR decline, supporting that complement activation and its measurement are clinically relevant in DN.
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Authors | Karyne Pelletier, Arnaud Bonnefoy, Hugo Chapdelaine, Vincent Pichette, Matthieu Lejars, François Madore, Soumeya Brachemi, Stéphan Troyanov |
Journal | Kidney international reports
(Kidney Int Rep)
Vol. 4
Issue 6
Pg. 797-805
(Jun 2019)
ISSN: 2468-0249 [Electronic] United States |
PMID | 31194090
(Publication Type: Journal Article)
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