Abstract | OBJECTIVE: DESIGN: SUBJECTS: INTERVENTION: None, observational study. MAIN OUTCOME MEASURE: RESULTS: The mean free testosterone level was significantly lower in the HD group than that in the C group and positively correlated with lean tissue index (LTI, r = 0.51, P = .001) and body cell mass (BCM, r = 0.57, P < .001). Significant, negative correlations were observed between free testosterone level and age (r = -0.4, P = .004) as well as fat tissue index (r = -0.36, P = .018). In a subgroup of men on hemodialysis who have low testosterone levels (<9.4 pg/mL), we observed a lower LTI and BCM and higher age, fat tissue index, and loginterleukin-6. In our receiver operating characteristic curve analysis, LTI and BCM were shown to be good predictors of a low testosterone level with cutoff points of 13.3 kg/m2 and 22.3 kg, respectively, meaning that men on hemodialysis with LTI <13.3 kg/m2 were 26 times more likely to have free testosterone levels below 9.4 pg/mL (odds ratio, 26.7; 95% confidence interval: 3.0-236.6). CONCLUSION: Low lean tissue mass and BCM can be predictors of low testosterone level.
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Authors | Aleksandra Rymarz, Anna Matyjek, Małgorzata Gomółka, Stanisław Niemczyk |
Journal | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
(J Ren Nutr)
Vol. 29
Issue 6
Pg. 529-535
(11 2019)
ISSN: 1532-8503 [Electronic] United States |
PMID | 31078405
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Body Composition
(physiology)
- Humans
- Hypogonadism
(epidemiology)
- Inflammation
- Kidney Failure, Chronic
(physiopathology, therapy)
- Male
- Middle Aged
- Nutritional Status
- Prospective Studies
- Renal Dialysis
- Testosterone
(blood, deficiency)
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