Abstract | BACKGROUND: METHODS: Three hundred six patients (including 142 patients with muscle-invasive bladder cancer and 164 patients with non-muscle-invasive bladder cancer) as well as 459 normal controls were included in this study. Two tag SNPs of OSMR, rs2278329, and rs2292016 were genotyped by TaqMan® SNP Genotyping Assay method and then the associations with bladder cancer were analyzed, as well as risk factors and prognosis. RESULTS: Patients with bladder cancer and controls did not differ significantly in terms of genotype frequencies and allele frequency distribution of rs2278329 (P = 0.77, OR = 0.97) and rs2292016 (P = 0.39, OR = 1.20) respectively. For rs2278329, no differences were found in terms of risk factors in stratified analyses. However, rs2292016 was associated with recurrence and tumor grade. GT/TT was found to increase the risk of relapse compared to the patients without allele T (GG genotype) (P = 0.016, OR = 1.878, 95% CI = 1.12-3.14) with the T allele of rs2292016 being a risk factor for recurrence (P = 0.032, OR = 0.67, 95% CI = 0.47-0.97). Besides, patients with GT genotype often present with high-grade bladder cancer (P = 0.003, OR = 2.33, 95% CI = 1.32-4.17). Multiple Cox regression analysis showed that rs2278329 and rs2292016 were related to the recurrence-free survival and overall survival in non muscle invasive bladder cancer ( NMIBC) patients. For rs2278329, GA genotype could affect recurrence-free survival (P = 0.01, OR = 2.16, 95% CI = 1.17-3.98). For rs2292016, TT/GT genotype had a lower risk of death compared with GG homozygote genotype, and T was a protective factor for overall survival in bladder cancer (P = 0.029, OR = 0.22, 95% CI = 0.06-0.86). CONCLUSIONS: OSMR genotype frequencies were found to be associated with higher recurrence in bladder cancer, and it may serve as a biomarker candidate gene to predict prognosis of this disease. Further validation of OSMR as biomarker is required.
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Authors | Shi Deng, Sheng Yin He, Pan Zhao, Peng Zhang |
Journal | World journal of surgical oncology
(World J Surg Oncol)
Vol. 17
Issue 1
Pg. 30
(Feb 12 2019)
ISSN: 1477-7819 [Electronic] England |
PMID | 30755233
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- OSMR protein, human
- Oncostatin M Receptor beta Subunit
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Topics |
- Aged
- Biomarkers, Tumor
(genetics)
- China
(epidemiology)
- Disease-Free Survival
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Recurrence, Local
(genetics, mortality, pathology)
- Oncostatin M Receptor beta Subunit
(genetics)
- Polymorphism, Single Nucleotide
- Prognosis
- Survival Analysis
- Urinary Bladder
- Urinary Bladder Neoplasms
(genetics, mortality, pathology)
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