Abstract | BACKGROUND:
Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is, therefore, of utmost importance to optimize physical and neurodevelopmental outcomes. DATA SOURCES: A PubMed search was completed in Clinical Queries using the key terms " hypothyroidism". RESULTS: CONCLUSIONS: To optimize neurocognitive outcome in infants with congenital hypothyroidism, treatment with levothyroxine should be started as soon as possible, preferably within the first 2 weeks of life. Children with acquired hypothyroidism should also be treated early to ensure normal growth and development as well as cognitive outcome. The target is to keep serum TSH < 5 mIU/L and to maintain serum free T4 or total T4 within the upper half of the age-specific reference range, with elimination of all symptoms and signs of hypothyroidism.
|
Authors | Alexander K C Leung, Alexander A C Leung |
Journal | World journal of pediatrics : WJP
(World J Pediatr)
Vol. 15
Issue 2
Pg. 124-134
(Apr 2019)
ISSN: 1867-0687 [Electronic] Switzerland |
PMID | 30734891
(Publication Type: Journal Article, Review)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Age Factors
- Child
- Child, Preschool
- Congenital Hypothyroidism
(diagnosis, drug therapy)
- Early Diagnosis
- Female
- Follow-Up Studies
- Humans
- Hypothyroidism
(diagnosis, drug therapy)
- Infant
- Infant, Newborn
- Male
- Neonatal Screening
- Risk Assessment
- Sex Factors
- Thyroid Function Tests
- Thyrotropin
(administration & dosage)
- Thyroxine
(administration & dosage)
- Treatment Outcome
|