Abstract | AIM: MATERIALS AND METHODS: 134 patients with NAFLD were examined: 54 with LS and 80 with SH. The control group consisted of 37 healthy donors. Anthropometric parameters (body mass index (BMI), waist circumference (WC)), clinical and biochemical blood indices, including the blood level of cytokeratin-18 fragments (CK-18), TNF-α and IL-6 cytokines, insulin were evaluated. The HOMA index and the fibrosis index ( NAFLD FS) were calculated. Patients were divided into groups: I - with the absence of IR (HOMA-index <2.7), II - with the presence of IR (HOMA-index> 2.7). RESULTS: Indicators of hepatic injury, inflammation, cholestasis, fibrosis and atherogenic dyslipidemia are higher in patients with LS of group II (with IR) than in group I patients (without IR). BMI, WC, γ-glutamil transpeptidase, CK-18 and fibrosis index are significantly higher in group II patients with SH compared with group I, there is no significant difference in the level of cytolysis, inflammation and dyslipidemia indices. A high incidence of IR in non-diabetic patients with LS (37.0%) and SH (55.0%) was found and the effect of IR on the clinical course of these diseases was revealed. CONCLUSION:
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Authors | A A Shipovskaya, O P Dudanova, I V Kurbatova |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 90
Issue 8
Pg. 63-68
(Aug 27 2018)
ISSN: 0040-3660 [Print] Russia (Federation) |
PMID | 30701940
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Insulin
- Keratin-18
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Topics |
- Adult
- Apoptosis
- Body Mass Index
- Cytokines
(blood)
- Female
- Fibrosis
- Humans
- Insulin
(blood)
- Insulin Resistance
- Keratin-18
(blood)
- Liver
(pathology)
- Liver Function Tests
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(blood, diagnostic imaging, pathology)
- Ultrasonography
- Waist Circumference
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