Abstract | BACKGROUND: AIM: METHODS: RESULTS: Biphasic peaks of scratching were observed at 1 h and at 6-7 h during an observation period of 14 h after trichophytin induction. For lesional skin, RNA was extracted 24 h after trichophytin challenge, and increased expression was seen in the genes for interleukin (IL)-17A, interferon-γ, tumour necrosis factor (TNF)-α, macrophage inflammatory protein (MIP)-2 and Dectin-1, whereas there was no obvious change in the genes for IL-31 and prostaglandin (PG)E2. Furthermore, KCZ inhibited histidine decarboxylase (HDC) expression in vitro and in vivo, and inhibited scratching in the very early phase. LNF inhibited expression of thymic stromal lymphopoietin (TSLP) and IL-8 in vitro, and TSLP, TNF-α, IL-1α and MIP2 in vivo, and also scratching in the early phase. TBF did not induce any significant alterations in either gene expression or scratching. DEX suppressed expression of all the chemical mediators except HDC in vitro and in vivo, and inhibited scratching. CONCLUSION:
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Authors | T Nakamura, N Yoshida, K Anzawa, A Nishibu, T Mochizuki |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 44
Issue 4
Pg. 381-389
(Jun 2019)
ISSN: 1365-2230 [Electronic] England |
PMID | 30187507
(Publication Type: Journal Article)
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Copyright | © 2018 British Association of Dermatologists. |
Chemical References |
- Antifungal Agents
- Chemokine CXCL2
- Cytokines
- Interleukin-17
- Lectins, C-Type
- Tumor Necrosis Factor-alpha
- dectin 1
- Trichophytin
- Interferon-gamma
- Thymic Stromal Lymphopoietin
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Topics |
- Animals
- Antifungal Agents
(pharmacology)
- Chemokine CXCL2
(metabolism)
- Cytokines
(drug effects, metabolism)
- Dermatitis, Contact
(diagnosis, drug therapy, etiology, metabolism)
- Disease Models, Animal
- Humans
- Interferon-gamma
(drug effects, metabolism)
- Interleukin-17
(metabolism)
- Keratinocytes
(metabolism)
- Lectins, C-Type
(drug effects, metabolism)
- Male
- Mice
- Mice, Inbred ICR
(metabolism)
- Mycoses
(diagnosis, drug therapy, metabolism)
- Pruritus
(immunology, metabolism, physiopathology)
- Tinea
(diagnosis, microbiology)
- Trichophytin
(adverse effects)
- Tumor Necrosis Factor-alpha
(drug effects, metabolism)
- Thymic Stromal Lymphopoietin
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