Abstract | BACKGROUND AND OBJECTIVE: METHODS: In this retrospective case series, we identified consecutive CTD-ILD patients treated with tacrolimus plus intravenous (i.v.) methylprednisolone (1000 mg i.v. 3 days a week for 2 weeks) followed by low-dose prednisolone (10 mg/day). We assessed the multidimensional therapeutic benefit and tolerability including lung physiology, exercise capacity, exercise oxygen desaturation, modified Medical Research Council (MMRC) and St George's Respiratory Questionnaire (SGRQ). RESULTS: A total of 26 ILD patients with the underlying CTD diagnoses included 11 with rheumatoid arthritis, 9 with dermatomyositis, 4 with Sjögren's syndrome and 2 others. From baseline to 12 months, the combined therapy significantly improved forced vital capacity (FVC; 77.8% to 94.6%, P < 0.001), diffusing capacity of the lung for carbon monoxide (DLCO ; 66.1% to 75.1%, P < 0.001), 6-min walk distance (6MWD; 530 to 568 m, P = 0.02), lowest oxygen saturation on pulse oximetry (SpO2 ; 85% to 89%, P = 0.01), MMRC (1.3 to 0.8, P = 0.01) and SGRQ (38 to 21, P < 0.001). During the study period, only one patient's therapy was discontinued due to an adverse event and none had a life-threatening adverse event attributed to the combined therapy. CONCLUSION:
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Authors | Yasuhiko Yamano, Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahiko Ando, Kensuke Kataoka, Taiki Furukawa, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto, Yoshinori Hasegawa |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 23
Issue 11
Pg. 1041-1048
(11 2018)
ISSN: 1440-1843 [Electronic] Australia |
PMID | 30011421
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 Asian Pacific Society of Respirology. |
Chemical References |
- Immunosuppressive Agents
- Prednisone
- Tacrolimus
- Methylprednisolone
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Topics |
- Aged
- Connective Tissue Diseases
(complications, drug therapy, pathology)
- Drug Therapy, Combination
(methods)
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Japan
- Lung
(pathology, physiopathology)
- Lung Diseases, Interstitial
(drug therapy, etiology, pathology)
- Male
- Methylprednisolone
(administration & dosage)
- Middle Aged
- Prednisone
(administration & dosage)
- Pulse Therapy, Drug
(methods)
- Respiratory Function Tests
(methods)
- Retrospective Studies
- Tacrolimus
(administration & dosage)
- Treatment Outcome
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