Abstract | OBJECTIVES: METHODS: RESULTS: The median (interquartile range, IQR) BALF PTX3 for aspergillosis cases was significantly higher than for non- aspergillosis cases: 6.97 (2.91-13.51) ng/mL versus 1.26 (0.76-1.76) ng/mL. When the PTX3 threshold was set at 1.9 ng/mL, sensitivity and specificity of BALF PTX3 for aspergillosis were 86.3% (95%CI 83.8-88.4%) and 82.5% (95%CI 79.7-85.0%), respectively. The median (IQR) plasma PTX3 for aspergillosis cases was significantly higher than for non- aspergillosis cases and healthy controls: 7.10 (3.36-9.53) ng/mL versus 1.57 (0.86-2.35) ng/mL versus 1.10 (0.49-1.51) ng/mL. With a PTX3 threshold of 2.3 ng/mL, sensitivity and specificity were 79.8% (95%CI 70.1-81.2%) and 72.1% (95%CI 69.5-74.5%) respectively. CONCLUSIONS:
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Authors | H Li, L Liu, W Zhou, Y Rui, B He, Y Shi, X Su |
Journal | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
(Clin Microbiol Infect)
Vol. 25
Issue 4
Pg. 504-510
(Apr 2019)
ISSN: 1469-0691 [Electronic] England |
PMID | 29964232
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Serum Amyloid P-Component
- PTX3 protein
- C-Reactive Protein
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Topics |
- Adult
- Aged
- Aspergillus fumigatus
(isolation & purification)
- Biomarkers
(analysis, blood)
- Bronchoalveolar Lavage Fluid
(chemistry)
- C-Reactive Protein
(analysis)
- Cryptococcosis
(blood)
- Female
- Humans
- Lung Neoplasms
(blood)
- Male
- Middle Aged
- Pneumonia
(blood)
- Prospective Studies
- Pulmonary Aspergillosis
(blood, diagnosis, microbiology)
- Serum Amyloid P-Component
(analysis)
- Young Adult
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