Invasive Pulmonary Aspergillosis

Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.

Also Known As:

Pulmonary Aspergillosis - Invasive; Allergic Bronchopulmonary Mycoses; Aspergillosis, Invasive Pulmonary; Bronchopulmonary Mycoses, Allergic; Bronchopulmonary Mycosis, Allergic; Mycoses, Allergic Bronchopulmonary; Mycosis, Allergic Bronchopulmonary; Pulmonary Aspergilloses, Invasive; Pulmonary Aspergillosis Invasive; Pulmonary Aspergillosis, Invasive; Allergic Bronchopulmonary Mycosis; Chronic Necrotizing Pulmonary Aspergillosis

Networked: 957 relevant articles (84 outcomes, 71 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aspergillosis
2.	Infections
3.	Neutropenia
4.	Lung Injury
5.	Sporotrichosis

Experts

1.	Walsh, Thomas J: 29 articles (01/2021 - 01/2002)
2.	Petraitiene, Ruta: 22 articles (01/2021 - 01/2002)
3.	Petraitis, Vidmantas: 21 articles (01/2021 - 01/2002)
4.	Lagrou, Katrien: 14 articles (01/2022 - 12/2009)
5.	Kontoyiannis, Dimitrios P: 14 articles (01/2020 - 10/2002)
6.	Hope, William W: 14 articles (01/2017 - 07/2006)
7.	Wiederhold, Nathan P: 13 articles (05/2015 - 10/2004)
8.	Bacher, John: 12 articles (01/2021 - 01/2002)
9.	Maertens, Johan: 11 articles (01/2022 - 12/2009)
10.	Bakker-Woudenberg, Irma A J M: 11 articles (01/2018 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Invasive Pulmonary Aspergillosis:

1.	Amphotericin B (Amphotericin)FDA LinkGeneric 11/01/1996 - "We believe that this positive outcome constitutes a change in the natural history of invasive pulmonary aspergillosis in neutropenic patients as a result of the early initiation of high dose amphotericin B. " 10/01/2005 - "The efficacy of nebulized amphotericin B formulations was evaluated in persistently granulocytopenic rats with invasive pulmonary aspergillosis. " 05/01/1997 - "Tolerance and efficacy of Amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in haematological patients." 03/01/1994 - "We investigated the safety and efficacy of amphotericin B colloidal dispersion (ABCD) for the treatment of invasive pulmonary aspergillosis in persistently granulocytopenic rabbits. " 02/01/2017 - "Amphotericin B nebulisation for invasive pulmonary aspergillosis prophylaxis: the conflict of ideality and reality."
2.	liposomal amphotericin B FDA Link 12/01/2005 - "Efficacy of high loading doses of liposomal amphotericin B in the treatment of experimental invasive pulmonary aspergillosis." 02/01/1993 - "Liposomal amphotericin B was evaluated for toxicity, pharmacokinetic properties and therapeutic efficacy in invasive pulmonary aspergillosis in Sprague-Dawley rats. " 05/01/2013 - "Efficacy of liposomal amphotericin B for prophylaxis of acute or reactivation models of invasive pulmonary aspergillosis." 05/01/2002 - "In common with a proportion of patients with invasive pulmonary aspergillosis (IPA), the efficacy of AmBisome treatment regimens in our rat model remains suboptimal. " 03/01/1999 - "The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. "
3.	galactomannanIBA 04/01/2000 - "It was concluded that, in this model, quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis." 04/01/2000 - "Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model." 01/01/2018 - "The present study investigated the improvement in the diagnosis of invasive pulmonary aspergillosis (IPA) adding a molecular test on bronchoalveolar lavage (BAL) to the routine diagnostic approach including microscopy, culture and galactomannan (GM) immunoassay. " 01/24/2023 - "Here, we present the long-term kinetics of serum galactomannan in two severely immunocompromised adolescents with invasive pulmonary aspergillosis (IPA) who were cured after complicated clinical courses. " 06/01/2014 - "Galactomannan detection in bronchoalveolar lavage (BAL) fluid samples (GM test) is currently considered the gold standard test for diagnosing invasive pulmonary aspergillosis (IPA). "
4.	Voriconazole (Vfend)FDA LinkGeneric 12/01/2008 - "A 74-year-old woman given a diagnosis of chronic necrotizing pulmonary aspergillosis in February, 2007 was treated by intravenous voriconazole (VRCZ) and her conditions improved. " 05/01/2000 - "Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model." 03/22/2023 - "Subsequent fungal cultures from his bronchoalveolar lavage were positive for Aspergillus niger and treatment with voriconazole was added for suspected invasive pulmonary aspergillosis (IPA). " 01/01/2023 - "[Translated article] Therapeutic drug monitoring of voriconazole in a rapid-metabolizer patient with invasive pulmonary aspergillosis." 01/01/2023 - "Therapeutic drug monitoring of voriconazole in rapid-metabolizer patient with invasive pulmonary aspergillosis."
5.	Itraconazole (Sporanox)FDA LinkGeneric 12/01/2006 - "Efficacy of intravenous itraconazole against invasive pulmonary aspergillosis in neutropenic mice." 04/01/2006 - "In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis." 01/01/2002 - "In vivo, the antifungal efficacy of itraconazole has been demonstrated in several non-immunocompromised and immunocompromised animal models of disseminated and invasive pulmonary aspergillosis. " 01/01/2003 - "The efficacy and safety of 2 weeks of intravenous itraconazole (200 mg twice daily for 2 days, then 200 mg once daily for 12 days) followed by 12 weeks of oral itraconazole capsules 200 mg twice daily were evaluated in a multicentre, open trial in 31 immunocompromised patients with invasive pulmonary aspergillosis (IPA). " 07/01/2021 - "Of 29 patients with IFD, only 9 developed IFD while on itraconazole prophylaxis (5.3%), all of whom had invasive pulmonary aspergillosis. "
6.	Micafungin (FK463)FDA Link 11/01/2009 - "We treated 26 patients with CPA, 19 with chronic necrotizing pulmonary aspergillosis (CNPA) and 7 with aspergilloma, with micafungin between February 2003 and September 2005. " 08/01/2007 - "Successful treatment of refractory chronic necrotizing pulmonary aspergillosis with micafungin." 06/01/2002 - "albicans in tissue, micafungin-treated rabbits with invasive pulmonary aspergillosis had no reduction in the concentration of Aspergillus fumigatus in tissue. " 06/01/2006 - "[Micafungin therapy for a case of chronic necrotizing pulmonary aspergillosis]." 05/01/2004 - "Successful micafungin (FK463) treatment of invasive pulmonary aspergillosis in a patient with acute lymphoblastic leukemia in a phase II study."
7.	TriazolesIBA 12/01/2022 - "Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China." 01/01/2022 - "Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis." 01/01/2019 - "Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. " 09/28/2018 - "Three isolates were collected from patients with invasive pulmonary aspergillosis, and four patients had no known previous triazole exposure. " 06/01/2014 - "A perA null mutant has decreased conidia production, increased susceptibility to triazole antifungal drugs, and is avirulent in a murine model of invasive pulmonary aspergillosis. "
8.	EchinocandinsIBA 01/01/2022 - "fumigatus to in vivo echinocandin treatment in a murine model of invasive pulmonary aspergillosis. " 05/01/2008 - "However, paradoxical attenuation of antifungal activity with increasing doses has been reported for some echinocandins in experimental models of invasive pulmonary aspergillosis (IPA). " 08/01/2010 - "Invasive pulmonary aspergillosis is a life-threatening infection in lung transplant recipients; however, no studies of the pharmacokinetics and pharmacodynamics (PKPD) of echinocandins in transplanted lungs have been reported. " 05/01/2015 - "Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis." 06/15/2003 - "The combination of an antifungal triazole and echinocandin may represent a new strategy for treatment of invasive pulmonary aspergillosis."
9.	Caspofungin (Cancidas)FDA Link 01/01/2017 - "fumigatus induced by caspofungin that was associated with airway eosinophil recruitment in neutropenic mice with invasive pulmonary aspergillosis (IA). " 04/01/2008 - "A high-dose-step-down strategy for caspofungin treatment was evaluated in an experimental model of advanced-stage invasive pulmonary aspergillosis. " 04/01/2008 - "Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis." 04/01/2006 - "Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis." 10/15/2004 - "A paucity of data exists regarding the pharmacodynamics of caspofungin (CAS) during invasive pulmonary aspergillosis (IPA). "
10.	AntigensIBA 01/01/2022 - "Performance of the Euroimmun Aspergillus Antigen ELISA for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid." 03/01/2014 - "We used mass spectrometry to identify an antigen that reacted with the serum of a patient with allergic bronchopulmonary mycosis caused by S. commune. " 01/01/2012 - "[Serum antigens assay combined with chest CT scan in diagnosis of invasive pulmonary aspergillosis]." 06/01/2007 - "He was found to have chronic necrotizing pulmonary aspergillosis based on a high titer of aspergillus antigen and positive antibody. " 12/01/2005 - "She was diagnosed with chronic necrotizing pulmonary aspergillosis, based on isolation for Aspergillus sp. in sputum culture and a positive reaction for Aspergillus antigen in bronchial lavage and Aspergillus antibody in serum. "

Therapies and Procedures

1.	Therapeutics 01/01/2022 - "These data demonstrate that prophylactic vaccination with VesiVax® Af3/9 is a promising method of protection against invasive pulmonary aspergillosis even as the changing face of the disease renders current therapies ineffective." 01/01/2022 - "Studies have not compared HVC and PCR for detection of Aspergillus species in respiratory samples from patients with suspected invasive pulmonary Aspergillosis (IPA) not on antifungal therapy. " 11/01/2013 - "Previous studies examining combination therapy for invasive pulmonary aspergillosis (IPA) have revealed conflicting results, including antagonism, indifference, and enhanced effects. " 05/01/2005 - "Guinea pig models have primarily been used in therapy studies of invasive pulmonary aspergillosis (IPA). " 10/28/2022 - "Quandaries of deciding when to change first-line therapy in invasive pulmonary aspergillosis."
2.	Liver Transplantation 07/01/2011 - "Invasive pulmonary aspergillosis after living donor liver transplantation should be eradicated or not? " 08/01/2012 - "The purpose of this study was to evaluate the radiological and clinical findings of invasive pulmonary aspergillosis (IPA) after liver transplantation. " 03/01/2012 - "The aim of this study was to evaluate the computed tomography (CT) and clinical features of invasive pulmonary aspergillosis (IPA) in liver transplant recipients. " 07/01/2023 - "Invasive pulmonary aspergillosis (IPA) in liver transplant patients remains rare but exceedingly fatal. " 07/01/2023 - "Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report."
3.	Stem Cell Transplantation 10/01/2023 - "Invasive pulmonary aspergillosis remains a major cause of morbidity and mortality for immunocompromised children, particularly for patients with acute leukaemia and those undergoing haematopoietic stem cell transplantation. " 02/10/2022 - "Molecular Profiling Reveals Characteristic and Decisive Signatures in Patients after Allogeneic Stem Cell Transplantation Suffering from Invasive Pulmonary Aspergillosis." 09/01/2004 - "Successful autologous stem cell transplantation in Ph-positive ALL patient with refractory invasive pulmonary aspergillosis." 01/01/1997 - "Invasive pulmonary aspergillosis complicated by subclavian artery occlusion following allogeneic stem cell transplantation." 01/01/1997 - "We describe an unusual case of invasive pulmonary aspergillosis (IPA) complicated by subclavian artery occlusion in a 32-year-old man with severe aplastic anemia, who underwent allogeneic stem cell transplantation. "
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/01/2002 - "The efficacy of KT MAbs against Aspergillus fumigatus was investigated in a mouse model of T-cell-depleted allogeneic bone marrow transplantation (BMT) with invasive pulmonary aspergillosis. " 01/26/2009 - "Invasive pulmonary aspergillosis 10 years post bone marrow transplantation: a case report." 04/01/2007 - "A boy, with the same diagnosis, underwent bone marrow transplantation from related donor but died from invasive pulmonary aspergillosis. " 06/15/2005 - "Because of the high risk of leukaemia-relapse bone marrow transplantation (BMT) from a matched unrelated donor was carried out despite invasive pulmonary aspergillosis (IPA). " 01/01/2002 - "To describe the clinical features and diagnostic aspects of invasive pulmonary aspergillosis (IPA) following bone marrow transplantation (BMT). "
5.	Induction Chemotherapy 05/01/2012 - "Complete remission could not be achieved even after several induction chemotherapy regimens, and the patient suffered from invasive pulmonary aspergillosis. " 01/01/2023 - "A 49-year-old woman with acute myeloid leukaemia developed invasive pulmonary aspergillosis after induction chemotherapy. " 10/01/2003 - "A 50-year-old man developed invasive pulmonary aspergillosis after induction chemotherapy for acute lymphoblastic leukemia. " 03/01/2002 - "After induction chemotherapy with IDR and AraC, the patient developed prolonged febrile neutropenia, and a diagnosis of invasive pulmonary aspergillosis was made. " 10/01/2003 - "[Invasive pulmonary aspergillosis complicated by complete atrioventricular block and aspergillus pericarditis after induction chemotherapy in a patient with acute lymphoblastic leukemia]."