Galectin-3-binding protein: A multitask glycoprotein with innate immunity functions in viral and bacterial infections.

Abstract

Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ongoing inflammation and microbial infection, such as IFN-α, IFN-β, IFN-γ, TNF-α, poly(I:C), dsRNA, and dsDNA. Furthermore, Gal-3BP belongs to the scavenger receptor cysteine-rich (SRCR) domain-containing protein family, by virtue of its N-terminal SRCR domain. The SRCR domain is found in soluble or membrane-associated innate immunity-related proteins and is implicated in self-nonself discrimination. This review summarizes the current knowledge of structural features of Gal-3BP and its proposed intracellular and extracellular innate immunity functions with special emphasis on viral and bacterial infections.

• Authors: Vuokko Loimaranta, Jussi Hepojoki, Olli Laaksoaho, Arto T Pulliainen
• Journal: Journal of leukocyte biology (J Leukoc Biol) Vol. 104 Issue 4 Pg. 777-786 (10 2018) ISSN: 1938-3673 [Electronic] England
• PMID: 29882603 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2018 Society for Leukocyte Biology.

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Carrier Proteins
• Glycoproteins
• LGALS3BP protein, human

Topics

• Antigens, Neoplasm (chemistry, genetics, immunology, physiology)
• Bacterial Infections (immunology)
• Biomarkers, Tumor (chemistry, genetics, immunology, physiology)
• Body Fluids (chemistry)
• Brain Chemistry
• Carrier Proteins (chemistry, genetics, immunology, physiology)
• Glycoproteins (chemistry, genetics, immunology, physiology)
• Humans
• Immunity, Innate
• Multigene Family
• Organ Specificity
• Protein Domains
• Species Specificity
• Structure-Activity Relationship
• Virus Diseases (immunology)
• Viscera (chemistry)