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Scavenger Receptors (Scavenger Receptor)

A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
Also Known As:
Scavenger Receptor; Macrophage Scavenger Receptor; Receptors, Scavenger; Acetyl-LDL Receptor; Acetyl-LDL Receptors; Acetylated LDL Receptor; Receptor, Acetyl-LDL; Receptor, Macrophage Scavenger; Acetyl LDL Receptor; Acetyl LDL Receptors; LDL Receptor, Acetylated; Receptor, Acetyl LDL; Receptor, Acetylated LDL; Receptor, Scavenger; Receptors, Acetyl-LDL; Macrophage Scavenger Receptors; Scavenger Receptors, Macrophage
Networked: 1566 relevant articles (48 outcomes, 140 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Febbraio, Maria: 17 articles (01/2020 - 10/2002)
2. Chen, Qi: 15 articles (01/2021 - 03/2011)
3. Bai, Hui: 14 articles (01/2021 - 03/2011)
4. Silverstein, Roy L: 14 articles (01/2020 - 10/2002)
5. Wang, Xiang-Yang: 14 articles (01/2020 - 05/2007)
6. Gordon, Siamon: 14 articles (01/2017 - 11/2004)
7. Ben, Jingjing: 12 articles (01/2021 - 11/2011)
8. Yang, Qing: 12 articles (01/2021 - 10/2012)
9. Zhang, Hanwen: 12 articles (01/2021 - 11/2011)
10. Zhu, Xudong: 12 articles (01/2021 - 11/2011)

Related Diseases

1. Atherosclerosis
2. Neoplasms (Cancer)
3. Infections
4. Hematoma
01/01/2018 - "BLVRA also induced the upregulation of CD36 scavenger receptor level in microglia/microphages, of which the prominent role is to enhance hematoma resolution. "
04/07/2022 - "CD163, alias hemoglobin (Hb) scavenger receptor on microglia, plays a pivotal role in hematoma absorption, but CD163 on neurons permits Hb uptake and results in neurotoxicity. "
03/01/2016 - "We evaluated if upregulating CD36 scavenger receptor expression in microglia and macrophages through PPARγ stimulation, which was effective in experimental adult cerebral hemorrhage models and is being evaluated clinically, will enhance hematoma resolution and ameliorate long-term brain sequelae using a neonatal rat germinal matrix hemorrhage model. "
07/01/2016 - "The monocyte-macrophage scavenger receptor, CD163, plays an important role in the metabolism of hemoglobin, and a soluble form of CD163 is present in plasma and other tissue fluids; therefore, we speculated that serum CD163 affects hematoma absorption after intracerebral hemorrhage. "
01/01/2023 - "Intranasal administration of r-FKN improved the short- and long-term neurobehavioral deficits and promoted M2 microglia polarization, thereby attenuating neuroinflammation and enhancing hematoma clearance, which was accompanied by an increased ratio of p-AMPK (phosphorylation of AMPK)/AMPK, Nrf2 (nuclear factor erythroid 2-related factor 2), PPARγ, CD36 (cluster of differentiation 36), CD163 (hemoglobin scavenger receptor), CD206 (the mannose receptor), and IL (interleukin)-10 expression, and decreased CD68 (cluster of differentiation 68), IL-1β, and TNF (tumor necrosis factor) α expression. "
5. Systemic Lupus Erythematosus (Libman-Sacks Disease)

Related Drugs and Biologics

1. HDL Lipoproteins
2. Cholesterol
3. Lipids
4. Proteins (Proteins, Gene)
5. Antibodies
6. oxidized low density lipoprotein
7. Cytokines
8. Scavenger Receptors (Scavenger Receptor)
9. Lipoproteins (Lipoprotein)
10. Ligands

Related Therapies and Procedures

1. Therapeutics
2. Sympathectomy (Sympathectomies)
3. Ligation
4. Punctures
5. Intranasal Administration