Abstract | BACKGROUND:
Obesity is considered to be a major comorbidity. Obese patients suffer from an increased proinflammatory state associated with a premature aging phenotype including increased secretion of senescence-associated secretory proteins (SASP) and reduced telomere length. Micro- ribonucleic acids ( miRNAs) are non-coding RNA molecules that could modify the post-transcriptional process. Several studies have reported associations between miRNAs and metabolic unhealthy conditions. AIM: METHODS: RESULTS: Patients showed a significant drop of body mass index (BMI; 43.98 ± 3.5 versus 28.02 ± 4.1, p < 0.001). We observed a significant reduction in SASP including a reduction of 55% of plasma IL-6 levels (p = 0 < 0.001), 83% of CRP levels (p = 0.001) and 15% of plasma PAI-1 levels (p < 0.001). Telomere length doubled in the patient cohort (p < 0.001) and was accompanied by a reduction in the telomere oxidation index by 70% (p < 0.001). Telomere length was inversely correlated with telomere oxidation. The aging-associated miRNA miR10a_5p was upregulated significantly (p = 0.039), while the other tested miRNAs showed no difference. CONCLUSION: Our data indicate a significant reduction of the proinflammatory SASP after bariatric surgery. We observed an increase in telomere length and reduced oxidative stress at telomeres. miR10a_5p which is downregulated during aging was upregulated after surgery. Overall, bariatric surgery ameliorated the premature aging phenotype.
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Authors | P J Hohensinner, C Kaun, B Ebenbauer, M Hackl, S Demyanets, D Richter, M Prager, J Wojta, Gersina Rega-Kaun |
Journal | Obesity surgery
(Obes Surg)
Vol. 28
Issue 9
Pg. 2804-2810
(09 2018)
ISSN: 1708-0428 [Electronic] United States |
PMID | 29693219
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aging, Premature
(blood, complications, epidemiology, genetics)
- Biomarkers
- Body Mass Index
- Gastric Bypass
(statistics & numerical data)
- Humans
- Obesity, Morbid
(complications, epidemiology, surgery)
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