Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206.

• Authors: Dasom Shin, Won Choi, Hyunsu Bae
• Journal: Toxins (Toxins (Basel)) Vol. 10 Issue 4 (04 02 2018) ISSN: 2072-6651 [Electronic] Switzerland
• PMID: 29614845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Bee Venoms
• Cytokines
• Dinitrochlorobenzene
• Lectins, C-Type
• Mannose Receptor
• Mannose-Binding Lectins
• Receptors, Cell Surface
• Immunoglobulin E
• Phospholipases A2

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Bee Venoms (enzymology)
• Cytokines (blood)
• Dermatitis, Atopic (drug therapy, metabolism)
• Dinitrochlorobenzene
• Immunoglobulin E (blood)
• Lectins, C-Type (genetics, metabolism)
• Male
• Mannose Receptor
• Mannose-Binding Lectins (genetics, metabolism)
• Mice, Inbred C57BL
• Mice, Knockout
• Phospholipases A2 (pharmacology, therapeutic use)
• Pyroglyphidae
• Receptors, Cell Surface (genetics, metabolism)