Dinitrochlorobenzene (DNCB)

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910 relevant articles (22 outcomes, 68 trials/studies) found for this Bio-Agent

Description: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.

Also Known As:

DNCB; 1-Chloro-2,4-Dinitrobenzene; 1 Chloro 2,4 Dinitrobenzene; Chlorodinitrobenzene; Benzene, 1-chloro-2,4-dinitro-

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 42

Hydrocarbons: 362

Halogenated Hydrocarbons: 31

Chlorinated Hydrocarbons: 137

Chlorobenzenes: 4

Dinitrochlorobenzene: 910

3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene: 1

1-chloro-2,4-dinitrobenzene-glutathione conjugate

2-carboxy-4,6-dinitrochlorobenzene

4-chloro-3,5-dinitrophenylmethyl sulfone

fluorodinitrochlorobenzene

Cyclic Hydrocarbons: 3

Aromatic Hydrocarbons: 121

Benzene Derivatives: 9

Nitrobenzenes: 5

Dinitrochlorobenzene: 910

3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene: 1

1-chloro-2,4-dinitrobenzene-glutathione conjugate

2-carboxy-4,6-dinitrochlorobenzene

4-chloro-3,5-dinitrophenylmethyl sulfone

fluorodinitrochlorobenzene

Chlorobenzenes: 4

Dinitrochlorobenzene: 910

3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene: 1

1-chloro-2,4-dinitrobenzene-glutathione conjugate

2-carboxy-4,6-dinitrochlorobenzene

4-chloro-3,5-dinitrophenylmethyl sulfone

fluorodinitrochlorobenzene

Nitro Compounds: 33

Nitrobenzenes: 5

Dinitrobenzenes: 4

Dinitrochlorobenzene: 910

3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene: 1

1-chloro-2,4-dinitrobenzene-glutathione conjugate

2-carboxy-4,6-dinitrochlorobenzene

4-chloro-3,5-dinitrophenylmethyl sulfone

fluorodinitrochlorobenzene

Biological Factors: 931

Antigens: 95584

Epitopes: 6437

Haptens: 318

Dinitrochlorobenzene: 910

3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene: 1

1-chloro-2,4-dinitrobenzene-glutathione conjugate

2-carboxy-4,6-dinitrochlorobenzene

4-chloro-3,5-dinitrophenylmethyl sulfone

fluorodinitrochlorobenzene

Experts

1.	Jörundsson, E: 2 articles (10/2004 - 08/2000)
2.	Gunnes, G: 2 articles (10/2004 - 08/2000)
3.	Landsverk, T: 2 articles (10/2004 - 08/2000)
4.	Kataranovski, Milena: 2 articles (06/2003 - 11/2002)
5.	Sripathi, H: 1 article (07/2008)
6.	Mohan, K H: 1 article (07/2008)
7.	Rao, Raghavendra: 1 article (07/2008)
8.	Balachandran, C: 1 article (07/2008)
9.	Prabhu, Smitha: 1 article (07/2008)
10.	Shenoi, S D: 1 article (07/2008)

Related Diseases

1.	Contact Dermatitis (Eczema, Contact) 01/01/1999 - "In the present study, CD4+ cell and gammadelta T-cell populations were of similar size in the normal and DNCB-treated lambs, suggesting an equal participation in the elicitation phase of contact hypersensitivity." 06/01/1993 - "Ultrastructural studies bearing on the mechanism of UVB-impaired induction of contact hypersensitivity to DNCB in man." 01/01/1989 - "The hapten in contact hypersensitivity to dinitrochlorobenzene: immunoelectron microscopic and immunofluorescent studies." 02/01/1980 - "In this study DNP-conjugates optimally inducing contact sensitivity in vivo were tested for their capacity to detect DNCB contact sensitivity in vitro in a lymphocyte transformation assay. " 01/01/1980 - "[Studies on the flare up reaction and the retest reaction in contact sensitivity to DNCB (author's transl)]" Order ALL the reference details at left...
2.	Hypersensitivity (Allergy) 09/01/1996 - "Improved results of delayed-type hypersensitivity skin testing in HIV-infected patients treated with topical dinitrochlorobenzene." 10/01/1995 - "Improved results of delayed-type hypersensitivity skin testing in HIV-infected patients treated with topical dinitrochlorobenzene." 01/01/1996 - "Delayed type hypersensitivity response (DTH) was induced as follows: six days after the second association trial session the mice were sensitized by smearing dinitrochlorobenezene (DNCB) on their abdominal skin. " 02/01/1975 - "Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded statistically significant positive correlations between the DNCB and PHA assays in twenty-one of twenty-eight instances, the DNCB and E rosette assays in thirteen of sixteen instances, the PHA and E rosette assays in twenty-eight of thirty-six instances, and among the DNCB, PHA and E rosette assays in ten of fourteen instances. " 01/01/1971 - "Studies on carrier substances of DNCB contact allergy." Order ALL the reference details at left...
3.	Delayed Hypersensitivity (Hypersensitivity, Type IV) 01/01/1975 - "Sensitization to BCG (Bacille Calmette-Guérin) appears to be more effective when it is carried out at the site of a delayed hypersensitivity challenge reaction to DNCB (1-chloro, 2,4-dinitrobenzene) than when it is carried out at unchallenged sites in non-sensitized animals. " 08/01/2002 - "The primary serum haemagglutinin response to sheep red blood cells and the primary cutaneous delayed hypersensitivity response to dinitrochlorobenzene were used to assess humoral and cell-mediated competence respectively, on day 28. " 02/01/2001 - "A synthetic peptide had the same selective anti-inflammatory features as the native material in comparable concentrations: in vitro inhibition of the locomotion in human peripheral blood monocytes, and of the respiratory burst in the same cells and in human neutrophil polymorphonuclear leucocytes; and in vivo depression of delayed hypersensitivity skin reactions to dinitrochlorobenzene in guinea pigs. " 09/01/1991 - "The delayed hypersensitivity reaction induced by sheep red blood cell (SRBC) or dinitrochlorbenzene (DNCB) in mice were also dramaticaly inhibited by FA 100, 200 mg.kg-1. " 09/01/1991 - "In addition, UV-radiated animals receiving the n-3 FA source demonstrated a reduced (approximately 30%) response to inflammatory stimulus and a greater (4.5-fold) delayed hypersensitivity (DH) to dinitrochlorobenzene than animals fed the n-6 FA source. " Order ALL the reference details at left...
4.	Neoplasms (Cancer) 12/01/1995 - "This report tries to compare the immunologic function of being take the Chinese medicine "Fu-Fang Shen Yang" or placebo C which is based on randomized clinical trials after operation for 238 cases of oral squamous cancer.DNCB test is for observable index.The" 07/01/1978 - "[Study of the DNCB skin test in patients with solid neoplasms]" 05/15/1990 - "GST pi activity towards 1-chloro-2,4-dinitrobenzene was found to be elevated in tumors from three out of six patients (patient nos. " 02/01/1988 - "Although the small size of the tumor samples precluded isoenzyme analysis by substrate specificities, analysis of GST activity following sample separation by isoelectric focusing indicated that the predominant (comprising at least 70% of the 1-chloro-2,4-dinitrobenzene-conjugating activity) GST isoenzyme in each of these primary tumor (17 of 17) and tumor cell line (3 of 3) extracts was anionic (isoelectric point, 4.5-4.8). " 12/15/1986 - "DNCB sensitization lineally decreased with increasing tumor progression. " Order ALL the reference details at left...
5.	Mumps 12/01/1981 - "Especially, decrease in incidence of positive CDH (DNCB and PHA) was found in stage III and IV. 2) There was no relationship between the incidence of positive CDH (SK-SD, Candida and Mumps) and clinical stage but, decrease in incidence of these tests was found in stage III and IV. 3) In comparison on numbers of positive CDH, there was no significance in control groups and cervical cancer patients. " 10/15/1979 - "Cutaneous responsiveness to Candida, Mumps-antigen, SK-SD, and DNCB as well as the cellular immune response to KLH were impaired in patients with Crohn's disease (significance was reached for SK-SD, DNCB, and the mean area of induration). " 08/01/1978 - "The skin tests with Varidase, Candidine, Mumps antigen and DNCB were not significantly different at onset and in remission. " 07/01/1980 - "(Candida, tuberculin, Streptokinase-dornase, and mumps) and failure to respond to contact sensitization to dinitrochlorobenzene was present in 60% of the patients. " 01/01/1979 - "Serum CH-50 levels and skin test responses to mumps, candida, trichophytin and dinitrochlorobenzene (DNCB) not found in vitro. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Dinitrochlorobenzene (DNCB)
2.	Antigens
3.	Tuberculin (PPD)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Immunoglobulin G (IgG)
6.	diphenylcyclopropenone
7.	Cyclophosphamide (Cytoxan)
8.	Immunoglobulin M (IgM)
9.	Dacarbazine (DIC)
10.	Haptens

Related Therapies and Procedures

1.	Immunotherapy
2.	Aftercare (After-Treatment)
3.	Intralesional Injections
4.	Lasers (Laser)
5.	Transplants (Transplant)

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