Abstract |
Alzheimer's disease (AD) is a progressive neurodegenerative disease with neither definitive pathogenesis nor effective treatment method so far. Huang-Lian-Jie-Du-Tang ( HLJDT) is a classic formula of traditional Chinese medicine (TCM) proven to have ameliorative effects on learning and memory deficits of dementia. Morris water maze (MWM) test and pathology analysis have demonstrated that HLJDT could ameliorate learning and memory deficits in AD mouse model, which may act via its anti- neuroinflammation properties. According to our previous studies, an UPLC-QTOF/MS-based metabolomics approach was performed to explore the potential mechanisms of HLJDT on preventing AD. As a result, a total of 23 potential metabolites (VIP >1, |Pcorr| >0.58, CUFjk excludes 0, P < 0.05) contributing to AD progress were identified. The metabolic pathway analysis with MetPA revealed that glycerophospholipid metabolism, sphingolipid metabolism, arachidonic acid metabolism, linoleic acid metabolism and tryptophan metabolism were disturbed in mouse model of AD. After HLJDT treatment, 14 metabolites were restored back to the control-like levels.
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Authors | Li-Min Sun, Bao-Jie Zhu, Hui-Ting Cao, Xin-Yi Zhang, Qi-Chun Zhang, Gui-Zhong Xin, Lin-Mei Pan, Li-Fang Liu, Hua-Xu Zhu |
Journal | Journal of pharmaceutical and biomedical analysis
(J Pharm Biomed Anal)
Vol. 151
Pg. 75-83
(Mar 20 2018)
ISSN: 1873-264X [Electronic] England |
PMID | 29310050
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier B.V. All rights reserved. |
Chemical References |
- Drugs, Chinese Herbal
- huang-lien-chieh-tu-tang
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Topics |
- Alzheimer Disease
(blood, drug therapy, genetics)
- Animals
- Chromatography, High Pressure Liquid
(methods)
- Drugs, Chinese Herbal
(metabolism, pharmacology, therapeutic use)
- Male
- Maze Learning
(drug effects, physiology)
- Medicine, Chinese Traditional
(methods)
- Metabolomics
(methods)
- Mice
- Mice, Transgenic
- Random Allocation
- Tandem Mass Spectrometry
(methods)
- Treatment Outcome
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