The Onset of Eosinophilic Pneumonia Preceding Anti-synthetase Syndrome.

Abstract

A 66-year-old man had been treated with prednisolone for eosinophilic pneumonia for 8 years. His slowly progressing cough and dyspnea were accompanied by elevated levels of fibrotic serological markers and an increased reticular shadow on chest computed tomography images. The patient had recently tested positive for anti-EJ antibodies, a type of anti-aminoacyl-tRNA synthetase antibody; therefore, we diagnosed him with an exacerbation of interstitial pneumonia due to anti-synthetase syndrome (ASS). He was treated with tacrolimus and an increased prednisolone dosage. We herein present the first reported case of eosinophilic pneumonia preceding anti-EJ antibody-positive ASS.

• Authors: Yoshimasa Hachisu, Yasuhiko Koga, Noriaki Sunaga, Chiharu Kashiwagi, Yuri Sawada, Yasuyuki Saito, Yusuke Tsukagoshi, Norimitsu Kasahara, Reiko Sakurai, Hiroaki Tsurumaki, Masakiyo Yatomi, Kyoichi Kaira, Akihiro Ono, Toshitaka Maeno, Takeshi Hisada
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 57 Issue 2 Pg. 247-251 (Jan 15 2018) ISSN: 1349-7235 [Electronic] Japan
• PMID: 29093389 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Amino Acyl-tRNA Synthetases

Topics

• Amino Acyl-tRNA Synthetases (immunology)
• Autoantibodies
• Cough (complications)
• Dyspnea (complications)
• Humans
• Lung Diseases, Interstitial (complications, diagnosis, immunology)
• Male
• Middle Aged
• Pulmonary Eosinophilia (complications)
• Syndrome
• Tomography, X-Ray Computed