Abstract | BACKGROUND: METHODS: Pancreatic euglycemic clamps were used to measure glucose kinetics alongside a central infusion of insulin or vehicle into the third ventricle. Male rats were pretreated with olanzapine or vehicle per our established model of acute olanzapine-induced peripheral insulin resistance. Groups included (central-peripheral) vehicle-vehicle (n = 11), insulin-vehicle (n = 10), insulin- olanzapine (n = 10) and vehicle- olanzapine (n = 8). RESULTS: LIMITATIONS: This study used only male rats and an acute dose of olanzapine. CONCLUSION: To our knowledge, this is the first study suggesting olanzapine may impair central insulin sensing, elucidating a potential mechanism of antipsychotic-induced diabetes and opening avenues of investigation related to domains of schizophrenia psychopathology.
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Authors | Chantel Kowalchuk, Celine Teo, Virginia Wilson, Araba Chintoh, Loretta Lam, Sri Mahavir Agarwal, Adria Giacca, Gary J Remington, Margaret K Hahn |
Journal | Journal of psychiatry & neuroscience : JPN
(J Psychiatry Neurosci)
Vol. 42
Issue 6
Pg. 424-431
(11 2017)
ISSN: 1488-2434 [Electronic] Canada |
PMID | 29083297
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Insulin
- Benzodiazepines
- Glucose
- Olanzapine
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Topics |
- Animals
- Antipsychotic Agents
(pharmacology)
- Benzodiazepines
(pharmacology)
- Brain
(drug effects, metabolism)
- Catheters, Indwelling
- Glucose
(metabolism)
- Infusions, Intraventricular
- Insulin
(administration & dosage, metabolism)
- Insulin Resistance
(physiology)
- Male
- Olanzapine
- Rats, Sprague-Dawley
- Subcutaneous Absorption
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