Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice.

Abstract

An insidious increase in the incidence of obesity, insulin resistance, and hyperlipidemia has led to an epidemic of type 2 diabetes worldwide. Tinospora crispa (T. crispa) is a familiar plant traditionally used in herbal medicine for diabetes; however, the major active ingredients of this plant are still unclear. In this study, we identified the therapeutic effects of borapetoside E, a small molecule extracted from T. crispa, in high-fat-diet (HFD)-induced obesity in mice. The therapeutic effects of borapetoside E in HFD-induced obese mice were assessed physiologically, histologically, and biochemically following intraperitoneal injection. Furthermore, we analyzed the expression of glucose and lipid metabolism-related genes and proteins in borapetoside E-treated obese mice. Compared with vehicle-treated mice, borapetoside E markedly improved hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice, and the effects were comparable to or better than the drug metformin. In addition, borapetoside E suppressed the expression of sterol regulatory element binding proteins (SREBPs) and their downstream target genes related to lipid synthesis in the liver and adipose tissue. Borapetoside E showed beneficial effects in vivo, demonstrating that borapetoside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.

• Authors: Yuhui Xu, Yanfen Niu, Yuan Gao, Fang Wang, Wanying Qin, Yanting Lu, Jing Hu, Li Peng, Jikai Liu, Wenyong Xiong
• Journal: Journal of natural products (J Nat Prod) Vol. 80 Issue 8 Pg. 2319-2327 (08 25 2017) ISSN: 1520-6025 [Electronic] United States
• PMID: 28742368 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diterpenes, Clerodane
• borapetoside E

Topics

• Animals
• Diabetes Mellitus, Type 2 (drug therapy)
• Diet, High-Fat
• Diterpenes, Clerodane (chemistry, isolation & purification, pharmacology)
• Hyperglycemia (metabolism)
• Hyperlipidemias (metabolism)
• Insulin Resistance
• Lipid Metabolism
• Liver (drug effects, metabolism)
• Mice
• Molecular Structure
• Phytotherapy
• Plants, Medicinal (chemistry)
• Tinospora (chemistry)