Sterol Regulatory Element Binding Proteins

Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.

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Networked: 237 relevant articles (2 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shimano, Hitoshi: 5 articles (01/2015 - 12/2003)
2.	Jiang, Tao: 4 articles (01/2020 - 09/2005)
3.	Yahagi, Naoya: 4 articles (06/2014 - 12/2003)
4.	Song, Bao-Liang: 3 articles (11/2022 - 02/2015)
5.	Baba, Osamu: 3 articles (01/2019 - 01/2013)
6.	Horie, Takahiro: 3 articles (01/2019 - 01/2013)
7.	Kimura, Takeshi: 3 articles (01/2019 - 01/2013)
8.	Kuwabara, Yasuhide: 3 articles (01/2019 - 01/2013)
9.	Nakao, Tetsushi: 3 articles (01/2019 - 01/2013)
10.	Nishiga, Masataka: 3 articles (01/2019 - 01/2013)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 01/01/2022 - "Enhanced de novo lipogenesis mediated by sterol regulatory element-binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. " 01/01/2019 - "Inappropriate activation of sterol regulatory element-binding proteins (SREBPs) can lead to non-alcoholic fatty liver disease (NAFLD). " 09/01/2007 - "Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)." 11/01/2022 - "Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis." 01/01/2022 - "Elevated sterol regulatory element-binding protein-driven (SREBP-driven) hepatocyte lipid synthesis is associated with NAFLD in humans and mice. "
2.	Insulin Resistance 02/01/2006 - "The divergence results from the use of two transcription start sites that produce two separate 5' exons, each of which is spliced to a common exon 2. Mutations in the sterol regulatory element binding protein gene (SREBF)-1 may contribute to insulin resistance states. " 04/01/2004 - "Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance?" 12/01/2012 - "We have shown previously that Elovl6 is a major target for sterol regulatory element binding proteins in the liver and that it plays a critical role in the development of obesity-induced insulin resistance by modifying FA composition. " 12/25/2015 - "Decreased UCP3 expression was linked to the development of selective insulin resistance in the heart, characterized by decreased basal activity of Akt but preserved activity of the p44/42 mitogen-activated protein kinase, and overactivation of the sterol regulatory element-binding protein (SREBP)-1-mediated lipogenic program. " 01/01/2015 - "The hepatic insulin resistance generated by Ccny depletion resulted in down-regulation of the sterol-regulatory element-binding protein (SREBP1) and fatty acid synthase (FASN). "
3.	Obesity 09/16/2005 - "The purpose of this study was to determine if there is altered renal lipid metabolism and increased expression of sterol regulatory element-binding proteins (SREBPs) in a model of diet-induced obesity. " 05/03/2002 - "Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humans." 12/01/2012 - "We have shown previously that Elovl6 is a major target for sterol regulatory element binding proteins in the liver and that it plays a critical role in the development of obesity-induced insulin resistance by modifying FA composition. " 11/01/2014 - "Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway." 09/01/2006 - "Obesity-induced hemodynamic changes and glomerular deposition of lipids (partly mediated by sterol regulatory element-binding proteins) play an important role in the pathogenesis of obesity-related renal disease. "
4.	Neoplasms (Cancer) 01/01/2020 - "Cancer cells increase lipogenesis for their proliferation and the activation of sterol regulatory element-binding proteins (SREBPs) has a central role in this process. " 03/01/2007 - "In particular, how the sterol-regulatory element binding protein, Akt and Hedgehog pathways may converge in cancer is reviewed." 01/01/2005 - "Since the microenvironment of solid tumors contains regions of poor oxygenation and high acidity, it has recently been suggested that cancer-associated FAS is a novel metabolic oncogene conferring a selective growth advantage upon stresses such as hypoxia and/or low pH. Here, we performed transient transfection studies with a 178-bp FAS promoter fragment harboring a complex Sterol Regulatory Element Binding Proteins (SREBP)-binding site to evaluate whether extracellular low pH and/or hypoxia may act in an epigenetic fashion by inducing changes in the transcriptional activation of FAS gene in cancer cells. " 01/01/2022 - "Activation of PI3K/Akt/mTOR signaling pathway induces transcription of the sterol regulatory element-binding proteins (SREBPs), which subsequently promotes cholesterol uptake and synthesis to meet the demand of cancer cells. " 01/23/2013 - "Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth."
5.	Hypoxia (Hypoxemia) 12/01/2015 - "In addition, a functional characterization of the homologue to the most important molecule involved in hypoxia responses in other fungi, the SREBP (sterol regulatory element binding protein) was performed. " 01/01/2015 - "The mutant for the sterol regulatory element-binding protein gene, MoSRE1, exhibited increased sensitivity to a hypoxia-mimicking agent, increased conidiation, and delayed invasive growth within host cells, which is suggestive of important roles in fungal development. " 03/01/2014 - "Transfection assays with a CYP51 promoter reporter gene revealed that FoxO4 and sterol regulatory element binding protein (SREBP)2 exert a stimulatory effect, whereas FoxO4 and the hypoxia inducible factor (HIF)2α repress CYP51 promoter activity. " 12/01/2012 - "The ability of this mold to adapt to hypoxia is important for fungal virulence and genetically regulated in part by the sterol regulatory element binding protein (SREBP) SrbA. " 07/30/2010 - "This is achieved through the activation of a transcriptional program affecting metabolic gene targets of hypoxia-inducible factor (HIF1alpha) and sterol regulatory element-binding protein (SREBP1 and SREBP2). "

Related Drugs and Biologics

1.	Peroxisome Proliferator-Activated Receptors (PPAR)
2.	Liver X Receptors
3.	Insulin (Novolin)
4.	Berberine
5.	Lipids
6.	Proteins (Proteins, Gene)
7.	SREBP cleavage-activating protein
8.	Cholesterol
9.	Fatty Acid Synthases (Fatty Acid Synthase)
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Electroacupuncture
4.	Therapeutics
5.	Oral Administration