Abstract | OBJECTIVE:
Olanzapine, an atypical antipsychotic, is associated with glucoregulatory abnormalities, but the nature of this link is not fully elucidated. This is the first olanzapine oral glucose tolerance test (oGTT) study to consider treatment dose and duration, and to compare complementary indices respectively assessing insulin sensitivity (Matsuda index) and resistance (homeostasis model assessment). METHODS: RESULTS: While only one previously undiagnosed participant met diabetes criteria based on fasting plasma glucose alone (≥126 mg/dL), seven were diagnosed with oGTT (2-hr plasma glucose ≥200 mg/dL). Multiple regression analyses revealed that the Matsuda index correlated with BMI (p < 0.0001) and plasma triglycerides (p = 0.01), but not with age, olanzapine dose, olanzapine treatment duration, or plasma cholesterol. Homeostasis model assessment and fasting plasma glucose correlated with triglycerides only (p < 0.0001 for both). CONCLUSIONS:
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Authors | Jeffrey Guina, Sayon Roy, Ankur Gupta, Daniel D Langleben, Igor Elman |
Journal | Human psychopharmacology
(Hum Psychopharmacol)
Vol. 32
Issue 4
(07 2017)
ISSN: 1099-1077 [Electronic] England |
PMID | 28573760
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 John Wiley & Sons, Ltd. |
Chemical References |
- Antipsychotic Agents
- Blood Glucose
- Triglycerides
- Benzodiazepines
- Olanzapine
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Topics |
- Adult
- Aged
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Benzodiazepines
(adverse effects, therapeutic use)
- Blood Glucose
(drug effects)
- Body Mass Index
- Dose-Response Relationship, Drug
- Female
- Glucose Tolerance Test
- Homeostasis
(drug effects)
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Olanzapine
- Psychotic Disorders
(drug therapy, metabolism)
- Regression Analysis
- Schizophrenia
(drug therapy, metabolism)
- Triglycerides
(blood)
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