Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers.

Abstract

Cancers have increased threat to human health due to the limited treatment efficacy of chemotherapy and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized. This study will provide a reference for the development and utilization of other natural products.

• Authors: Xianjuan Kou, Jingjing Fan, Ning Chen
• Journal: Anti-cancer agents in medicinal chemistry (Anticancer Agents Med Chem) Vol. 17 Issue 12 Pg. 1610-1616 ( 2017) ISSN: 1875-5992 [Electronic] Netherlands
• PMID: 28403777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Flavonoids
• Reactive Oxygen Species
• ampelopsin

Topics

• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Synergism
• Endoplasmic Reticulum Stress (drug effects)
• Flavonoids (chemistry, pharmacology, therapeutic use)
• Humans
• Molecular Structure
• Neoplasms (drug therapy, metabolism, pathology, prevention & control)
• Neovascularization, Pathologic (prevention & control)
• Reactive Oxygen Species (metabolism)