Abstract | BACKGROUND/AIMS: METHODS: Diabetes (DM) was induced by ip. streptozotocin administration in adult male Sprague-Dawley rats, followed by eight weeks of treatment with the (P)RR blocker "handle region" decoy peptide (HRP, 0,1 mg/kg/day) or with the ACE inhibitor Quinapril (Q, 50 mg/kg/day) and grouped as follows: 1. Control (n=10); 2. DM (n=8); 3. DM+HRP (n=6); 4. DM+Q (n=10); 5. DM+Q+HRP (n=10). Renal functional parameters, histology and gene expressions were evaluated. RESULTS: HRP reduced glomerulosclerosis and podocyte desmin expression, but did not affect proteinuria and tubular ERK(1/2) phosphorylation. Both Q and Q+HRP treatment reduced proteinuria, glomerular and tubular damage, tubular TGF-ß1 expression and ERK(1/2) phosphorylation to the same extent. CONCLUSION: The effects of HRP were partially beneficial on diabetic kidney lesions as HRP reduced damage but did not improve tubular damage and failed to reduce ERK(1/2) phosphorylation in rats. The combination of HRP with Quinapril had no additive effects over Quinapril monotherapy on the progression of diabetic nephropathy.
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Authors | Gábor Kökény, Lilla Fang, Csaba Révész, Miklós M Mózes, Péter Vörös, Gábor Szénási, László Rosivall |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 42
Issue 1
Pg. 109-122
( 2017)
ISSN: 1423-0143 [Electronic] Switzerland |
PMID | 28359068
(Publication Type: Journal Article)
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Copyright | © 2017 The Author(s)Published by S. Karger AG, Basel. |
Chemical References |
- Tetrahydroisoquinolines
- Renin
- Quinapril
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Topics |
- Animals
- Diabetes Mellitus, Experimental
- Diabetic Nephropathies
(drug therapy)
- Drug Interactions
- Drug Therapy, Combination
- Kidney
(drug effects, pathology)
- MAP Kinase Signaling System
(drug effects)
- Male
- Quinapril
- Rats
- Rats, Sprague-Dawley
- Renin
(pharmacology, therapeutic use)
- Tetrahydroisoquinolines
(pharmacology, therapeutic use)
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