Plasma levels of soluble intercellular adhesion molecule-1 as a biomarker for disease severity of patients with community-acquired pneumonia.

Abstract

BACKGROUND:

Community-acquired pneumonia (CAP) is characterized as an acute inflammation of the lung associated with the activation of macrophages and neutrophils. Intercellular adhesion molecule-1 (ICAM-1) is an essential adhesion molecule involved in immune cell recruitment in lung inflammation. We investigated whether ICAM-1 is a useful biomarker for assessing the disease severity of hospitalized adult patients with CAP.

METHODS:

Plasma soluble ICAM-1 (sICAM-1) levels were measured in 78 patients with CAP and 69 healthy controls by using a commercial enzyme-linked immunosorbent assay. The pneumonia severity index scores were used to determine CAP severity in patients upon initial hospitalization.

RESULTS:

The sICAM-1 and C-reactive protein (CRP) levels decreased significantly in patients with CAP after antibiotic treatment. The plasma concentration of sICAM-1 alone, but not CRP, was correlated with CAP severity according to the pneumonia severity index scores (r=0.431, p<0.001). The sICAM-1 levels in patients with CAP with high mortality risk were significantly higher than those in patients with CAP with medium or low mortality risk. Moreover, the sICAM-1 level showed a significant correlation with the length of hospital stay (r=0.488, p<0.001). Mechanistic investigations found that bacterial lipopolysaccharide induced upregulation of ICAM-1 expression through the c-Jun N-terminal kinase pathway in RAW264.7 macrophages.

CONCLUSIONS:

Plasma sICAM-1 levels may play a role in the diagnosis and clinical assessment of CAP severity.

• Authors: Pin-Yu Chang, Shih-Ming Tsao, Jer-Hwa Chang, Ming-Hsien Chien, Wen-Yueh Hung, Yi-Wen Huang, Shun-Fa Yang
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 463 Pg. 174-180 (Dec 01 2016) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 27983998 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Lipopolysaccharides
• Intercellular Adhesion Molecule-1
• C-Reactive Protein
• MAP Kinase Kinase 4

Topics

• Aged
• Aged, 80 and over
• Animals
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Case-Control Studies
• Cell Line
• Community-Acquired Infections (blood, drug therapy, mortality)
• Female
• Humans
• Intercellular Adhesion Molecule-1 (blood, metabolism)
• Length of Stay
• Lipopolysaccharides (pharmacology)
• MAP Kinase Kinase 4 (metabolism)
• Macrophages (drug effects, metabolism)
• Male
• Mice
• Middle Aged
• Pneumonia (blood, drug therapy, mortality)
• Pneumonia, Bacterial (blood, drug therapy)
• Prognosis