Abstract | BACKGROUND AND AIM: METHODS: Fasting blood samples were collected to measure PYY (ng/mL), PP (ng/mL), NPY (pg/mL), interleukin-6 (IL-6) (ng/mL), monocyte chemoattractant protein (MCP) 1 (ng/mL), and tumour necrosis factor (TNF) α (ng/mL). Modified Poisson regression analysis and linear regression analyses were conducted. Age, sex, ethnicity, obesity, diabetes, aetiology, time from 1st attack of AP, recurrence, severity, physical activity, and smoking were adjusted for in several statistical models. P<0.05 was considered statistically significant. RESULTS: A total of 93 patients were recruited. Peptide YY was significantly associated (p<0.001) with IL-6, MCP-1, and TNFα in the unadjusted and all adjusted models. Pancreatic polypeptide was significantly associated (p<0.001) with IL-6, MCP-1, and TNFα in the unadjusted and at least one adjusted model. Peptide YY and PP together contributed 22.2%, 72.7%, and 34.6% to the variance of IL-6, MCP-1, and TNFα, respectively. Neuropeptide Y was not significantly associated with any of the three cytokines. CONCLUSIONS:
Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after AP and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFα. Future research is warranted to investigate the signaling pathways that underlie these associations.
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Authors | Sayali A Pendharkar, Ruma G Singh, Maxim S Petrov |
Journal | Cytokine
(Cytokine)
Vol. 90
Pg. 161-168
(02 2017)
ISSN: 1096-0023 [Electronic] England |
PMID | 27918953
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
Chemical References |
- Cytokines
- Neuropeptide Y
- Peptide YY
- Pancreatic Polypeptide
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Topics |
- Acute Disease
- Adult
- Aged
- Cytokines
(blood, immunology)
- Fasting
(blood)
- Female
- Follow-Up Studies
- Humans
- Immunity, Innate
- Male
- Middle Aged
- Neuropeptide Y
(blood, immunology)
- Pancreatic Polypeptide
(blood, immunology)
- Pancreatitis
(blood, immunology, therapy)
- Peptide YY
(blood, immunology)
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