Pancreatic Polypeptide (Pancreatic Polypeptide (PP))

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

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Networked: 791 relevant articles (8 outcomes, 61 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Pendharkar, Sayali A: 5 articles (01/2020 - 01/2017)
2.	Petrov, Maxim S: 5 articles (01/2020 - 01/2017)
3.	Singh, Ruma G: 5 articles (01/2020 - 01/2017)
4.	Bloom, Stephen R: 5 articles (02/2016 - 01/2008)
5.	Davis, Stephen N: 5 articles (01/2015 - 07/2004)
6.	Cryer, Philip E: 5 articles (04/2004 - 04/2002)
7.	Davis, S N: 5 articles (06/2001 - 01/2000)
8.	Sainsbury, Amanda: 4 articles (12/2015 - 05/2002)
9.	Banarer, Salomon: 4 articles (05/2003 - 04/2002)
10.	Tate, D: 4 articles (06/2001 - 01/2000)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2008 - "The relationship between tumor location considering the embryological structure of the pancreas and the site of PLX invasion was investigated with an immunohistochemical study using pancreatic polypeptide. " 08/05/2019 - "Pancreatic Polypeptide-secreting tumor of the distal pancreas (PPoma) is a rare, difficult and indolent type of cancer with a survival rate of 5-year in only 10% of all cases. " 06/01/2009 - "Pancreatic polypeptide (PP) is expressed in pancreatic islets and is known to be expressed in pancreatic endocrine tumors. " 08/01/2008 - "Their diagnosis was established by the presence of an enhancing solitary pancreatic tumor on computed tomography (CT) and elevated fasting pancreatic polypeptide hormone levels. " 08/01/2008 - "Sporadic pancreatic polypeptide secreting tumors (PPomas) of the pancreas."
2.	Chronic Pancreatitis 01/01/1994 - "The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). " 02/01/2002 - "In both acute and chronic pancreatitis, changes in plasma concentration of pancreatic polypeptide (PP) and its regulation have been reported. " 01/01/2001 - "Pancreatic Polypeptide Secretion in Patients with Chronic Pancreatitis and After Pancreatic Surgery." 01/01/2001 - "Pancreatic polypeptide secretion in patients with chronic pancreatitis and after pancreatic surgery." 10/01/1996 - "Chronic pancreatitis (CP) is associated with lowered plasma levels and a blunted nutrient-induced release of pancreatic polypeptide (PP). "
3.	Type 2 Diabetes Mellitus (MODY) 08/18/2023 - "Correction to "A Reduced Pancreatic Polypeptide Response is Associated With New-onset Pancreatogenic Diabetes Versus Type 2 Diabetes"." 01/01/2023 - "A Reduced Pancreatic Polypeptide Response is Associated With New-onset Pancreatogenic Diabetes Versus Type 2 Diabetes." 03/01/1987 - "Pancreatic polypeptide: marker for autonomic neuropathy but not for lean NIDDM." 07/01/1985 - "Pancreatic polypeptide: a marker for lean non-insulin-dependent diabetes mellitus?" 09/01/2012 - "Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes."
4.	Ganglion Cysts (Ganglion) 01/01/1982 - "Pancreatic polypeptide appears to be relayed from its cells of origin to a neurohaemal organ in the dorsal sheath of the thoracic ganglion. " 01/01/1993 - "FMRFamide and bovine pancreatic polypeptide (BPP) immunoreactivities were detected in the cerebral ganglion and in the alimentary tract of the protochordate ascidian Styela plicata. " 12/02/1985 - "Distinct localization of FMRFamide- and bovine pancreatic polypeptide-like material in the brain, retrocerebral complex and suboesophageal ganglion of the cockroach Periplaneta americana L." 01/01/1984 - "Gastrin/CCK-like and secretin-like immunoreactive materials appear to co-exist in the cells of the corpus cardiacum and co-existence of gastrin/CCK-like and pancreatic polypeptide-like substances occurs within certain cells of the thoracic ganglion." 01/01/1982 - "Prolactin-immunoreactive and pancreatic polypeptide-immunoreactive cells were argyrophilic with the Grimelius' stain and were found in neighbouring positions in the cerebral ganglion. "
5.	Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis) 02/05/1982 - "Multiple endocrine adenomatosis type I. Occurrence in an octogenarian with high levels of circulating pancreatic polypeptide." 02/01/1997 - "An immunohistochemical investigation of pancreatic-polypeptide (PP) cells in the PP-rich region of the pancreas, of ventral embryological origin, was performed in three female patients affected by or previously operated on for functioning duodenal or pancreatic gastrinomas not associated with multiple endocrine neoplasia syndrome. " 12/01/1983 - "Pancreatic polypeptide update: its roles in detection of the trait for multiple endocrine adenopathy syndrome, type I and pancreatic polypeptide-secreting tumors." 01/01/1978 - "Serum levels of pancreatic polypeptide in Zollinger-Ellison syndrome, and hyperparthyroidism from families with multiple endocrine adenomatosis type I." 01/01/1978 - "Mean fasting levels of pancreatic polypeptide (PP) in 24 patients with Zollinger-Ellison syndrome (ZES) and in 12 patients with hyperparathyroidism originating from families with multiple endocrine adenomatosis type I (MEAI-HPT) were significantly higher than in 72 normal controls. "

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2.	Glucagon (Glukagon)
3.	Somatostatin (Somatotropin Release-Inhibiting Factor)
4.	Glucose (Dextrose)
5.	Chromogranin A
6.	Phosphopyruvate Hydratase (Enolase)
7.	salicylhydroxamic acid (SHAM)
8.	Blood Glucose (Blood Sugar)
9.	S100 Proteins (S 100 Protein)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Subcutaneous Infusions
4.	Intravenous Injections
5.	Electroacupuncture