Abstract | BACKGROUND: PROCEDURE: In a prospective study, 43 children receiving treatment for ALL were monitored for mucosal toxicity from diagnosis through the induction phase of treatment. Serial blood draws were taken to determine the levels of SP-D, interleukin-6 (IL-6), C-reactive protein, and white blood cells. Data on fever, antibiotics, and bacteremia were collected. Baseline levels of circulating SP-D were compared with healthy controls. RESULTS: Baseline values of circulating SP-D were similar to levels in healthy controls (median: 829 ng/ml vs. 657 ng/ml, respectively, P > 0.05). After initiation of chemotherapy, a significant reduction in SP-D levels was observed at all time points: 704 ng/ml at day 8, 413 ng/ml at day 15, 395 ng/ml at day 22, and 520 ng/ml at day 29 (all, P < 0.05). No significant associations between SP-D values, the occurrence of mucosal toxicity, or infectious morbidity were observed. However, loss of circulating SP-D from days 8 to 15 was associated with more systemic inflammation, and lower SP-D values at day 15 were associated with elevated intestinal mucositis scores (P < 0.05). CONCLUSIONS: The current study supports the hypothesis that the detrimental effect of chemotherapy on patients' immune functions includes decreased circulating levels of innate mucosal molecules such as SP-D, potentially aggravating mucosal and systemic inflammatory responses.
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Authors | Mathias Rathe, Grith L Sorensen, Peder S Wehner, Uffe Holmskov, Per T Sangild, Kjeld Schmiegelow, Klaus Müller, Steffen Husby |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 64
Issue 3
(03 2017)
ISSN: 1545-5017 [Electronic] United States |
PMID | 27667327
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 Wiley Periodicals, Inc. |
Chemical References |
- IL6 protein, human
- Interleukin-6
- Pulmonary Surfactant-Associated Protein D
- C-Reactive Protein
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Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- C-Reactive Protein
(analysis)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Infant
- Interleukin-6
(blood)
- Male
- Mucositis
(blood, chemically induced, diagnosis)
- Mucous Membrane
(drug effects)
- Neoplasm Staging
- Pneumonia
(blood, chemically induced, diagnosis)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(blood, drug therapy, pathology)
- Prognosis
- Prospective Studies
- Pulmonary Surfactant-Associated Protein D
(blood)
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