Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

8242  relevant articles (847 outcomes, 969 trials/studies) found for this Disease

Acute Lymphoblastic Leukemia; Acute Lymphocytic Leukemia; Lymphoblastic Leukemia; ALL, Childhood; Acute Lymphoid Leukemia; Leukemia, Lymphoblastic, Acute; Leukemia, Lymphoblastic, Acute, L1; Leukemia, Lymphoblastic, Acute, L2; Leukemia, Lymphoblastic, Acute, Philadelphia-Positive; Leukemia, Lymphocytic, Acute; Leukemia, Lymphocytic, Acute, L1; Leukemia, Lymphocytic, Acute, L2; Lymphoblastic Leukemia, Acute; Lymphoblastic Leukemia, Acute, Adult; Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Leukemia, Acute, L1; Lymphoblastic Leukemia, Acute, L2; Lymphocytic Leukemia, L1; Lymphocytic Leukemia, L2; Childhood ALL; L1 Lymphocytic Leukemia; L2 Lymphocytic Leukemia; Leukemia, Acute Lymphoblastic; Leukemia, Acute Lymphocytic; Leukemia, Acute Lymphoid; Leukemia, L1 Lymphocytic; Leukemia, L2 Lymphocytic; Lymphoid Leukemia, Acute; Lymphomas, Lymphoblastic; Precursor Cell Lymphoblastic Leukemia Lymphoma; Leukemia, Lymphoblastic; Leukemia, Lymphoid, Acute; Lymphoblastic Lymphoma; Lymphocytic Leukemia, Acute; Lymphoma, Lymphoblastic

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
2.	Leukemia
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
4.	Philadelphia Chromosome
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Experts

1.	Pui, Ching-Hon: 23 articles (05/2008 - 07/2002)
2.	Relling, Mary V: 17 articles (05/2008 - 07/2002)
3.	Pieters, Rob: 15 articles (10/2008 - 02/2003)
4.	Schrappe, Martin: 15 articles (09/2008 - 06/2002)
5.	Hoelzer, Dieter: 15 articles (12/2007 - 01/2002)
6.	Evans, William E: 14 articles (04/2008 - 07/2002)
7.	Pieters, R: 12 articles (09/2008 - 08/2000)
8.	Ottmann, Oliver G: 12 articles (05/2008 - 01/2002)
9.	Krawczuk-Rybak, Maryna: 12 articles (11/2007 - 08/2002)
10.	Kantarjian, Hagop: 11 articles (10/2008 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Precursor Cell Lymphoblastic Leukemia-Lymphoma:

1.	Methotrexate (Mexate)FDA LinkGeneric 10/01/2005 - "PURPOSE: Intravenous methotrexate (IV-MTX), an effective treatment for acute lymphoblastic leukemia (ALL), has a significant toxic effect on the central nervous system, with leukoencephalopathy (LE) being the most common form. " 05/01/2005 - "BACKGROUND AND PURPOSE: An effective treatment for acute lymphoblastic leukemia (ALL), intravenous (IV) methotrexate (MTX) has a notable toxic effect on the CNS, with leukoencephalopathy (LE) being the most common form. " 02/01/2001 - "BACKGROUND AND OBJECTIVES: Methotrexate (MTX) is a key drug in the curative regimen of children with acute lymphocytic leukemia. " 01/01/1985 - "Seventy-two successfully treated patients with acute lymphocytic leukemia, all in first complete remission and all off therapy, who had received CNS prophylaxis (radiotherapy, 2,400 rad, plus intrathecal methotrexate), were studied by computed tomography (CT) of the brain, EEGs, and neurologic evaluations 3 to 9 years after the end of prophylaxis. " 05/01/1997 - "Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?" Order ALL the reference details at left...
2.	Vincristine (Oncovin)FDA LinkGeneric 04/01/1990 - "An 11 year-old girl was diagnosed as acute lymphoblastic leukemia (ALL) on November 26th 1979 and was induced into complete remission with vincristine and prednisolon. " 02/01/2008 - "The microtubule-depolymerizing drug, vincristine, is effective in the treatment of acute lymphoblastic leukemia (ALL). " 01/01/1982 - "One child with acute lymphocytic leukemia resistant to vincristine had a transient M1 remission bone marrow. " 09/01/2006 - "Trial initiated for liposomal vincristine in relapsed/refractory acute lymphoblastic leukemia." 01/01/2006 - "Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia." Order ALL the reference details at left...
3.	Cytarabine (Cytosar-U)FDA LinkGeneric 12/01/2001 - "Cytosine arabinoside has been less well studied in relation to childhood ALL, although evidence exists to suggest that the administration of conventional-dose bolus or infusion schedules may not be optimal in terms of the antileukaemic efficacy of this antimetabolite. " 12/01/1998 - "Our results show the efficacy of the intermediate dose ARA-C plus IDA schedule for high risk adult and childhood ALL patients. " 09/15/1987 - "Low-dose cytosine arabinoside-induced remission of lymphoblastic leukemia in a cat." 10/04/1980 - "Whereas in the 1960s only 4/19 achieved (short) remission, now, since the introduction of cytosine arabinoside, remissions are observed on 79% but median survival (10 months) is still short compared with acute lymphocytic leukemia. " 12/01/2008 - "In the present study, the sensitivity of cytarabine (1-beta-D-arabinofuranosylcytosine, araC)-resistant and parental human leukemic cell lines (T-lymphoid H9 and acute T-lymphoblastic leukemia Molt-4) to natural killer (NK) cell-mediated killing was investigated. " Order ALL the reference details at left...
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/01/2000 - "The current approach of allogeneic BMT from an unrelated donor when no sibling donor is available, following conditioning with cyclophosphamide/ fractionated TBI has resulted in a reduced relapse rate and improved short-term overall survival in the treatment of relapsed childhood ALL. " 02/16/1963 - "[Trial treatment by cyclophosphamide of acute lymphoblastic leukemia and lymphoblastosarcoma.]" 03/01/1981 - "Cyclophosphamide was administered to 42 patients with acute lymphocytic leukemia (ALL) as a daily continuous iv infusion at a dose of 400 mg/m2/day x 5 days; the courses of treatment were repeated every 3 weeks. " 02/01/1977 - "Children with B-lymphoblastic lymphoma usually benefit from cyclophosphamide therapy; the value of irradiation is yet to be established. " 09/01/2002 - "A 26-year-old male with acute lymphoblastic leukemia (ALL) in its second complete remission received an unrelated bone marrow transplantation (UBMT) following cyclophosphamide plus total body irradiation conditioning. " Order ALL the reference details at left...
5.	imatinib (Gleevec)FDA Link 09/01/2005 - "Efficacy of imatinib mesylate as maintenance therapy in adults with acute lymphoblastic leukemia in first complete remission." 10/01/2004 - "Using quantitative reverse-transcription polymerase chain reaction we investigated the significance of achieving molecular complete remission (CR) in 12 patients with bcr/abl-positive acute lymphocytic leukemia treated with imatinib. " 10/01/2004 - "The achievement of molecular complete remission during treatment with imatinib mesylate correlates with relapse-free survival in bcr/abl-positive acute lymphoid leukemia patients." 10/01/2003 - "Philadelphia-negative acute lymphoblastic leukemia developing in a CML patient in imatinib mesylate-induced complete cytogenetic remission." 11/01/2005 - "In addition, imatinib is much less effective in advanced phase-CML as well as in Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL), mainly due to the development of drug resistance. " Order ALL the reference details at left...
6.	Prednisone (Sone)FDA LinkGeneric 06/01/2009 - "The purpose of this study was to assess time-resolved changes in Bax activation and its intracellular distribution as well as the percentage of apoptotic cells evaluated by PARP cleavage in response to prednisone treatment in childhood ALL. " 01/01/2009 - "METHODS: In the present prospective trial, 15 children with acute lymphoblastic leukemia and hyperleukocytosis (range 101-838 x 10(9)/l) were treated with intravenous low-dose prednisone continuous infusion (6 mg/m(2)/24 h). " 09/01/2008 - "Initial leukemic gene expression profiles of patients with poor in vivo prednisone response are similar to those of blasts persisting under prednisone treatment in childhood acute lymphoblastic leukemia." 05/01/2008 - "Prednisone induces immunophenotypic modulation of CD10 and CD34 in nonapoptotic B-cell precursor acute lymphoblastic leukemia cells." 11/01/2007 - "[Clinical, morphologic immunologic and cytogenetic characteristics of childhood acute lymphoblastic leukemia: a comparison between prednisone poor responders and good responders]" Order ALL the reference details at left...
7.	Asparaginase (Elspar)FDA Link 12/01/2008 - "The outcome of pediatric acute lymphoblastic leukemia (ALL) has improved dramatically over the last 40 years through a systematic approach of well-designed large trials including use of asparaginase. " 02/01/2008 - "OBJECTIVE: L-asparaginase (ASNase) is one of the most effective chemotherapeutic means for inducing remission in acute lymphoblastic leukemia. " 05/01/1987 - "We studied platelet function and plasma coagulation parameters in 12 pediatric patients with acute lymphoblastic leukemia (ALL) receiving daily L-asparaginase as a single agent when in complete remission. " 07/01/1995 - "Asparaginase is an effective treatment for patients with acute lymphocytic leukemia (ALL). " 10/01/1977 - "The findings were consistent with reports that L-asparaginase is effective in suppressing cellular immunity and inducing remission in patients with acute lymphocytic leukemia, mainly a non-B-cell disease. " Order ALL the reference details at left...
8.	6-Mercaptopurine (Mercaptopurine)FDA LinkGeneric 01/01/2000 - "6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). " 02/01/1985 - "The antipurine 6-mercaptopurine (6-MP) is effective in the induction and maintenance of remission in patients with acute lymphocytic leukemia. " 01/01/1991 - "To evaluate the reasons for the wide variability in bioavailability of orally administered 6-mercaptopurine in children with acute lymphoblastic leukemia, we studied several pharmacokinetic parameters of the drug in 18 affected children receiving remission maintenance therapy, and compared them with their anthropometric data and with the results of intestinal function tests. " 11/01/1989 - "Plasma levels of 6-mercaptopurine were determined in 22 consecutive children with acute lymphoblastic leukemia on oral remission maintenance therapy during the time period of August 1984 to January 1988. " 01/01/1988 - "In three children receiving oral remission maintenance therapy for acute lymphoblastic leukemia, the concentrations of 6-mercaptopurine (6-MP) in cerebrospinal fluid (CSF), plasma and red blood cells were compared. " Order ALL the reference details at left...
9.	Doxorubicin (Adriamycin)FDA LinkGeneric 01/01/1981 - "Low-dose adriamycin remission maintenance for advanced acute lymphoblastic leukemia: a Southwest Oncology, Group study." 03/21/1991 - "We therefore assessed the cardiac status of 115 children who had been treated for acute lymphoblastic leukemia with doxorubicin 1 to 15 years earlier in whom the disease was in continuous remission. " 06/01/1988 - "Improved treatment results for lymphoblastic lymphoma in adolescents and adults using a doxorubicin-based (APO) protocol." 07/01/2002 - "Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study." 05/01/2002 - "Pharmacokinetics of doxorubicin in children with acute lymphoblastic leukemia: multi-institutional collaborative study." Order ALL the reference details at left...
10.	AntigensIBA 02/01/2008 - "In children with acute lymphoblastic leukemia (ALL) with isolated central nervous system (CNS) relapse and a human leucocyte antigen (HLA)-matched sibling, the optimal treatment after attaining second remission is unknown. " 03/01/1990 - "Significance of common acute lymphoblastic leukemia antigen (cALLA) positive cells in bone marrow of children off therapy in complete remission." 03/01/1991 - "After a median follow-up of 2.1 years, there were also no statistically significant associations between myeloid antigen expression and shorter duration of remission or poorer survival rate for patients with both adult and childhood ALL." 11/16/1984 - "Detection of rare common acute lymphoblastic leukemia antigen (CALLA)-positive cells in peripheral blood is significantly improved by using multiple flow cytometric parameters to exclude a variety of mature blood cells which may nonspecifically bind the antibody reagent. " 04/01/1993 - "To answer basic questions regarding leukemic cell survival kinetics, a human acute lymphoblastic leukemia (ALL) cell line (Reh), with the common ALL antigen (CALLA-positive), has been used to assess in vitro the efficacy of one widely used hyperfractionated TBI (HTBI) regimen versus single dose TBI (SDTBI). " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2005 - "The aim of our study was to find which progenitor cells are most suitable for the preparation of dendritic cells in acute lymphoblastic leukemia (ALL) in pediatric patients, whether blasts from bone marrow or dendritic cells generated from peripheral blood mononuclear cells taken at the time of remission after induction chemotherapy. " 05/01/1997 - "Studies in the last decade show that most adults with acute lymphocytic leukemia (ALL) can achieve remission with intensive induction chemotherapy. " 01/01/2002 - "It is concluded that good results in childhood ALL treatment can be achieved without resorting to high-dosage chemotherapy and radiation in most cases." 07/01/2001 - "Most prognostic factors in childhood acute lymphoblastic leukemia (ALL) are informative for groups of patients, whereas new approaches are needed to predict the efficacy of chemotherapy for the individual patient. " 06/01/1976 - "Most of criteria on duration of chemotherapy in acute lymphoblastic leukemia of children are based upon the prolonged state of complete remission (CR). " Order ALL the reference details at left...
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 12/01/1993 - "In a retrospective multicentre study, we analyzed 184 consecutive patients who underwent bone marrow transplantation (BMT) from identical siblings for adult acute lymphoblastic leukemia in first complete remission between March 1980 and May 1989. " 09/01/2009 - "Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia." 10/01/2006 - "A 42-year-old woman was referred to us for the treatment of relapsed Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL), which had been maintained in complete remission for seven years after an allogeneic bone marrow transplantation (allo-BMT) from an unrelated donor. " 07/01/2005 - "Donor leukocyte infusion (DLI) alone has very limited efficacy for patients with acute lymphoblastic leukemia (ALL) who have relapsed after allogeneic bone marrow transplantation (BMT). " 02/01/2004 - "The role of allogeneic bone marrow transplantation (alloBMT) in adults with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) remains controversial. " Order ALL the reference details at left...
3.	Transplants (Transplant) 10/01/1989 - "Among the former, the most common condition is acute lymphoblastic leukemia, in which a bone marrow transplant can be performed during the second or first complete remission (CR). " 09/01/2009 - "Transplant decisions for children with acute lymphoblastic leukemia (ALL) in second complete remission (CR2) are often based on the type of available donor. " 07/15/2008 - "We report the retrospective outcomes of unrelated donor (URD) transplants in 169 patients with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) who received transplants between 1995 and 2004. " 07/15/2008 - "Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission." 06/01/2008 - "The relative advantage of transplant from compatible related donors in very-high-risk childhood acute lymphoblastic leukemia was consistent for any time elapsed in first remission." Order ALL the reference details at left...
4.	Transplantation (Transplant Recipients) 10/08/1981 - "This study demonstrates that marrow transplantation currently offers the best chance of long-term remission and potential cure after a child with acute lymphoblastic leukemia has had a relapse in the marrow." 06/20/2007 - "Transplantation in childhood very high risk acute lymphoblastic leukemia in first complete remission: where are we now?" 09/01/2002 - "An 11-month-old boy with acute lymphoblastic leukemia (ALL) underwent umbilical cord blood transplantation (CBT) from an unrelated donor after a first complete remission. " 03/01/1990 - "Allogenic versus autologous marrow transplantation for patients with acute non lymphoblastic leukemia in first complete remission." 09/01/2004 - "This approach offers a promising treatment option for patients with acute lymphoblastic leukemia needing urgently transplantation but lacking a suitable donor." Order ALL the reference details at left...
5.	Stem Cell Transplantation 10/01/1998 - "BACKGROUND AND OBJECTIVE: The best post-remission therapy for patients with acute lymphoblastic leukemia (ALL) is controversial, and hemopoietic stem cell transplantation (HSCT) is one therapeutic option. " 02/01/2006 - "To evaluate the results of autologous stem cell transplantation (ASCT) in a large population of adults with acute lymphoblastic leukemia (ALL) in first complete remission (CR), we performed an individual data-based overview of the last three trials from the LALA group. " 02/01/2006 - "Autologous stem cell transplantation in adults with acute lymphoblastic leukemia in first complete remission: analysis of the LALA-85, -87 and -94 trials." 09/01/2004 - "We performed HLA-mismatched stem cell transplantations with megadoses of purified positively selected mobilized peripheral blood CD34+ progenitor cells (PBPC) from adult donors in 27 children with acute lymphoblastic leukemia (ALL) in first (CR1 n = 7), second (CR2 n = 10), or third (CR3 n = 4) complete remission, and in refractory state (NR n = 6). " 09/01/2003 - "The authors present their experience with dose calculation of Retin1,1-hydroxyethylidene-186-diphosphonate (Re-186 HEDP) therapy used as part of an intensified conditioning regimen before allogeneic stem cell transplantation in 2 patients with advanced acute lymphoblastic leukemia during the second partial or third complete remission. " Order ALL the reference details at left...