Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Among 340 study participants (T2DM, n=66; pre-diabetes, n=202; NGT, n=72), the proportion of subjects with NAFLD increased according to the glucose tolerance status (31.9% in NGT; 47.0% in pre-diabetes; 57.6% in T2DM). The median CAP value was significantly higher in subjects with T2DM (265 dB/m) than in those with pre-diabetes (245 dB/m) or NGT (231 dB/m) (all p<0.05). Logistic regression analysis showed that subjects with moderate to severe NAFLD had a 2.8-fold (odds ratio) higher risk of having T2DM than those without NAFLD (p=0.02; 95% confidence interval, 1.21-6.64), and positive correlations between the CAP value and HOMA-IR (ρ0.407) or fasting C-peptide (ρ0.402) were demonstrated. CONCLUSION: Subjects with T2DM had a higher prevalence of severe NAFLD than those with NGT. Increased hepatic steatosis was significantly associated with the presence of T2DM, and insulin resistance induced by hepatic fat may be an important mechanistic connection.
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Authors | Young Eun Chon, Kwang Joon Kim, Kyu Sik Jung, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Chae Yoon Chon, Jae Bock Chung, Kyeong Hye Park, Ji Cheol Bae, Kwang Hyub Han |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 57
Issue 4
Pg. 885-92
(Jul 2016)
ISSN: 1976-2437 [Electronic] Korea (South) |
PMID | 27189281
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- C-Peptide
- Glycated Hemoglobin A
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Topics |
- Adult
- Aged
- Biomarkers
(metabolism)
- C-Peptide
(metabolism)
- Case-Control Studies
- Diabetes Mellitus, Type 2
(complications, metabolism)
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(epidemiology, metabolism, pathology)
- Odds Ratio
- Prevalence
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