Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: We searched MEDLINE, LILACS, and Cochrane data bases of clinical trials between January 1995 and January 2016, for quantitative MR imaging volumetric approaches, MR spectroscopy, diffusion tensor imaging, or other quantitative techniques, comparing patients with polyglutamine expansion spinocerebellar ataxias (SCAs) with controls. Pertinent details for each study regarding participants, imaging methods, and results were extracted. RESULTS: After reviewing the 706 results, 18 studies were suitable for inclusion: 2 studies in SCA1, 1 in SCA2, 15 in SCA3, 1 in SCA7, 1 in SCA1 and SCA6 presymptomatic carriers, and none in SCA17 and dentatorubropallidoluysian atrophy. Cerebellar hemispheres and vermis, whole brain stem, midbrain, pons, medulla oblongata, cervical spine, striatum, and thalamus presented significant atrophy in SCA3. The caudate, putamen and whole brain stem presented similar sensitivity to change compared with ataxia scales after 2 years of follow-up in a single prospective study in SCA3. MR spectroscopy and DTI showed abnormalities only in cross-sectional studies in SCA3. Results from single studies in other polyglutamine expansion spinocerebellar ataxias should be replicated in different cohorts. CONCLUSIONS: Additional cross-sectional and prospective volumetric analysis, MR spectroscopy, and DTI studies are necessary in polyglutamine expansion spinocerebellar ataxias. The properties of preclinical disease biomarkers (presymptomatic) of MR imaging should be targeted in future studies.
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Authors | A Klaes, E Reckziegel, M C Franca Jr, T J R Rezende, L M Vedolin, L B Jardim, J A Saute |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 37
Issue 8
Pg. 1405-12
(Aug 2016)
ISSN: 1936-959X [Electronic] United States |
PMID | 27173364
(Publication Type: Journal Article, Systematic Review)
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Copyright | © 2016 by American Journal of Neuroradiology. |
Topics |
- Adult
- Female
- Humans
- Male
- Neuroimaging
(methods)
- Spinocerebellar Ataxias
(diagnostic imaging, pathology)
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