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Ataxia (Dyssynergia)

Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Also Known As:
Dyssynergia; Lack of Coordination; Ataxias; Incoordination; Ataxia, Appendicular; Ataxia, Limb; Ataxia, Motor; Ataxia, Sensory; Ataxia, Truncal; Ataxy; Dyscoordination; Tremor, Rubral; Appendicular Ataxia; Appendicular Ataxias; Ataxias, Appendicular; Ataxias, Limb; Ataxias, Motor; Ataxias, Sensory; Ataxias, Truncal; Coordination Impairments; Coordination Lack; Impairment, Coordination; Impairments, Coordination; Incoordinations; Limb Ataxia; Limb Ataxias; Motor Ataxia; Motor Ataxias; Rubral Tremor; Rubral Tremors; Sensory Ataxia; Sensory Ataxias; Tremors, Rubral; Truncal Ataxia; Truncal Ataxias; Coordination Impairment
Networked: 6364 relevant articles (302 outcomes, 410 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Tremor (Tremors)
2. Constipation
3. Seizures (Absence Seizure)
4. Spinocerebellar Ataxias (Spinocerebellar Ataxia)
5. Headache (Headaches)

Experts

1. Hadjivassiliou, Marios: 41 articles (01/2022 - 03/2003)
2. Schöls, Ludger: 33 articles (01/2022 - 02/2002)
3. Klockgether, Thomas: 32 articles (01/2022 - 05/2004)
4. Durr, Alexandra: 19 articles (01/2022 - 01/2010)
5. Houlden, Henry: 19 articles (01/2022 - 05/2010)
6. Giunti, Paola: 19 articles (01/2021 - 03/2012)
7. Synofzik, Matthis: 18 articles (01/2022 - 12/2012)
8. Pandolfo, Massimo: 17 articles (01/2021 - 08/2004)
9. Bertini, Enrico: 16 articles (11/2021 - 10/2003)
10. Manto, Mario: 15 articles (01/2022 - 08/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ataxia:
1. Intravenous Immunoglobulins (IVIG)FDA Link
2. Thiamine (Aneurin)FDA Link
3. salicylhydroxamic acid (SHAM)IBA
01/01/2023 - "Anodal ctDCS led to a significant improvement in the Scale for the Assessment and Rating of Ataxia (-6.5%) and in the cerebellar cognitive affective syndrome scale (+11%) compared with sham ctDCS. "
01/06/2023 - "Comparing real and sham-rTMS interventions, the utilization of rTMS on cerebellum improved the scale for the assessment and rating of ataxia (SARA) (SMD - 0.87, 95% CI - 1.41 to - 0.34; P = 0.001; I2 = 62%), the International Cooperative Ataxia Rating Scale (ICARS) (SMD - 1.06, 95% CI - 1.47 to - 0.64; P < 0.00001; I2 = 0%) and Berg balance Scale (BBS) (SMD 0.76, 95% CI 0.33 to 1.19; P = 0.0005; I2 = 39%). "
11/01/2020 - "The International Cooperative Ataxia Rating Scale score also improved after active stimulation versus sham [median (interquartile range) of 29.0 (21.0, 43.5) versus 32.8 (22.0, 47.0); p = 0.005]. "
01/01/2023 - "Each patient underwent a clinical evaluation (Scale for the Assessment and Rating of Ataxia, composite cerebellar functional severity score, cerebellar cognitive affective syndrome scale) before and after anodal and sham ctDCS. "
01/01/2023 - "rTMS could significantly improve the Scale for the Assessment and Rating of Ataxia (SARA) (MD: -2.00; 95% CI: -3.97 to -0.02, p = 0.05), International Cooperative Ataxia Rating Scale (ICARS) (MD: -3.96; 95% CI: -5.51 to -2.40, p < 0.00001), Timed Up-and-Go test (TUG) (MD: -1.54; 95% CI: -2.24 to -0.84, p < 0.0001), 10-m walk test (10 MWT) (MD10-m steps: -2.44; 95% CI: -4.14 to -0.73, p = 0.005), and Berg Balance Scale (BBS) (MD: 2.59; 95% CI: 1.15-4.03, p = 0.0004) as compared to sham stimulation. "
4. SteroidsIBA
5. Gabapentin (Neurontin)FDA LinkGeneric
6. Acetazolamide (Diamox)FDA LinkGeneric
7. Valproic Acid (Depakote)FDA LinkGeneric
8. MethylprednisoloneFDA LinkGeneric
9. acetylleucineIBA
10. coenzyme Q10 (CoQ10)IBA

Therapies and Procedures

1. Therapeutics
2. Psychology Biofeedback (Biofeedback)
3. Transcranial Direct Current Stimulation
4. Injections
5. Physical Therapy Modalities (Physical Therapy Technique)