Treating IgE-mediated diseases via targeting IgE-expressing B cells using an anti-CεmX antibody.

Abstract

Targeting the IgE pathway is a clinically validated strategy for treating IgE-mediated diseases. Omalizumab, an anti-IgE antibody, which binds to free IgE and prevents the binding of IgE to FcεRI on mast cells and basophils has been approved for severe persistent allergic asthma and chronic spontaneous (idiopathic) urticaria. The therapeutic efficacy of anti-IgE has also been reported in allergic rhinitis, allergic bronchopulmonary aspergillosis, latex allergy, atopic dermatitis, allergic urticaria, anaphylaxis, and others. Anti-CεmX, which binds to membrane-bound IgE (mIgE) on IgE-switched B cells, lyses mIgE-expressing B lymphoblasts and prevents the allergen-induced generation of IgE-producing plasma cells, offers an alternative mechanism of intervening with the IgE inflammatory pathway. Because anti-CεmX does not bind to free IgE, it can modulate the IgE pathway regardless of the serum IgE levels in treated patients. These unique pharmacologic mechanisms potentially enable anti-CεmX to provide different clinical utilities from anti-IgE and serve as a therapeutic and a prophylactic in some IgE-mediated diseases, which are not adequately treated with current medicine.

• Authors: Sean S Liour, Andrew Tom, Yueh-Hsuan Chan, Tse Wen Chang
• Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (Pediatr Allergy Immunol) Vol. 27 Issue 5 Pg. 446-51 (08 2016) ISSN: 1399-3038 [Electronic] England
• PMID: 27090058 (Publication Type: Journal Article, Review)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antibodies, Monoclonal, Humanized
• Omalizumab
• Immunoglobulin E

Topics

• Animals
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Antibody-Dependent Cell Cytotoxicity
• Asthma (drug therapy)
• B-Lymphocytes (immunology, metabolism)
• Humans
• Immunoglobulin E (immunology, metabolism)
• Immunosuppression Therapy
• Lymphocyte Depletion
• Omalizumab (therapeutic use)
• Rhinitis, Allergic (drug therapy)
• Urticaria (drug therapy)