Abstract | BACKGROUND: MATERIALS AND METHODS: Endoscopies of the upper and lower gastrointestinal (GI) tract in 10 patients with metastatic renal cell carcinoma (mRCC) who developed diarrhea during treatment with VEGFR TKIs were performed. RESULTS: CONCLUSION: We observed frequent mucosal abnormalities in the upper GI tract in VEGFR TKI-treated mRCC patients with diarrhea. Although these abnormalities provide insufficient explanation for the occurrence of diarrhea, we suggest to perform routine upper GI endoscopy in VEGFR TKI-treated patients with GI complaints.
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Authors | Marye J Boers-Sonderen, Sasja F Mulder, Iris D Nagtegaal, Lauranne A A P Derikx, Geert J A Wanten, Peter F A Mulders, Winette T A van der Graaf, Frank Hoentjen, Carla M L van Herpen |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 55
Issue 4
Pg. 444-8
( 2016)
ISSN: 1651-226X [Electronic] England |
PMID | 26959411
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Indoles
- Protein Kinase Inhibitors
- Pyrroles
- Receptors, Vascular Endothelial Growth Factor
- Sunitinib
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Topics |
- Aged
- Antineoplastic Agents
(adverse effects)
- Capsule Endoscopy
(methods)
- Carcinoma, Renal Cell
(drug therapy, pathology)
- Diarrhea
(chemically induced, pathology)
- Endoscopy, Gastrointestinal
(methods)
- Female
- Humans
- Indoles
(adverse effects)
- Intestinal Mucosa
(diagnostic imaging, drug effects, pathology)
- Kidney Neoplasms
(drug therapy, pathology)
- Male
- Middle Aged
- Protein Kinase Inhibitors
(adverse effects)
- Pyrroles
(adverse effects)
- Receptors, Vascular Endothelial Growth Factor
(antagonists & inhibitors)
- Sunitinib
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