Atherosclerotic Vessel Changes in Sarcoidosis.

Abstract

Sarcoidosis is a systemic granulomatous disease. Atherosclerosis is a chronic inflammatory vessel disease. The aim of our present study was to investigate whether sarcoidosis could be associated with increased risk of atherosclerotic vessel changes. Angiological analysis and blood tests were performed in 71 sarcoidosis patients and 12 matched controls in this prospective cross-sectional study. Specifically, angiological measurements comprised ankle brachial index (ABI), central pulse wave velocity (cPWV), pulse wave index (PWI), and duplex sonography of central and peripheral arteries. Sarcoidosis activity markers (angiotensin converting enzyme, soluble interleukin-2 receptor) and cardiovascular risk parameters such as cholesterol, lipoprotein(a), C-reactive protein, interleukin 6, fibrinogen, d-dimer, and blood count were analyzed in blood. We found no relevant differences in ABI, cPWV, and plaque burden between the sarcoidosis and control groups (1.10 ± 0.02 vs. 1.10 ± 0.02, 6.7 ± 0.5 vs. 6.1 ± 1.2, 53.7 % vs. 54.5 %, respectively). However, PWI was significantly higher in sarcoidosis patients (146.2 ± 6.8) compared with controls (104.9 ± 8.8), irrespectively of the activity of sarcoidosis and immunosuppressive medication. Except for increased lipoprotein(a) and d-dimer in sarcoidosis, the remaining cardiovascular markers were similar in both groups. We conclude that sarcoidosis is associated with increased pulse wave index, which may indicate an early stage of atherosclerosis.

• Authors: I Tuleta, S Pingel, L Biener, C Pizarro, C Hammerstingl, C Öztürk, N Schahab, C Grohé, G Nickenig, C Schaefer, D Skowasch
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) 2016 Vol. 910 Pg. 23-30 ISSN: 0065-2598 [Print] United States
• PMID: 26820732 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL
• Fibrin Fibrinogen Degradation Products
• IL6 protein, human
• Interleukin-6
• Lipoprotein(a)
• Receptors, Interleukin-2
• fibrin fragment D
• Fibrinogen
• C-Reactive Protein
• Cholesterol
• Peptidyl-Dipeptidase A

Topics

• Ankle Brachial Index
• Atherosclerosis (diagnostic imaging, epidemiology, metabolism, physiopathology)
• Biomarkers (metabolism)
• Blood Flow Velocity
• C-Reactive Protein (metabolism)
• Cardiovascular Diseases (diagnostic imaging, epidemiology, metabolism)
• Case-Control Studies
• Cholesterol (metabolism)
• Cholesterol, HDL (metabolism)
• Cholesterol, LDL (metabolism)
• Cross-Sectional Studies
• Female
• Fibrin Fibrinogen Degradation Products (metabolism)
• Fibrinogen (metabolism)
• Humans
• Interleukin-6 (metabolism)
• Lipoprotein(a) (metabolism)
• Male
• Middle Aged
• Peptidyl-Dipeptidase A (metabolism)
• Plaque, Atherosclerotic (diagnostic imaging, epidemiology, metabolism, physiopathology)
• Prospective Studies
• Pulse Wave Analysis
• Receptors, Interleukin-2 (metabolism)
• Risk Factors
• Sarcoidosis (epidemiology, metabolism)
• Ultrasonography