Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender.

Abstract

Background Obesity is associated with a state of systemic inflammation, mediated by adipose tissue-derived cytokines that may also have metabolic effects, including an effect on insulin resistance. The aim of this study was to compare the serum profile of pro- and anti-inflammatory cytokines in obese and non-obese subjects. Methods A total of 242 subjects who were either overweight or obese (body mass index [BMI] ≥ 25 kg/m2) and non-obese subjects (body mass index <25 kg/m2), were recruited in Mashhad in northeastern Iran. The concentrations of serum interleukin-1α, -1β, -2, -4, -6, -8 and -10 (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), were measured in all subjects, together with serum vascular endothelial growth factor, interferon-γ, epidermal growth factor, monocyte chemoattractant protein-1 and tumour necrosis factor-α. Results The groups differed significantly with respect to measures of adiposity and fasted lipid profile. Serum pro-inflammatory cytokines interferon-γ and interleukin-1α, and anti-inflammatory cytokines, interleukin-10, and epidermal growth factor were significantly different between obese and non-obese individuals, as was serum high-sensitivity C-reactive protein. Multivariate regression showed that waist circumference was significantly and independently related to serum monocyte chemoattractant protein-1concentrations ( P = 0.001). Conclusion Despite significant differences in several cytokines between the groups, only monocyte chemoattractant protein-1appeared to be independently related to a measure of adiposity in this population sample from Iran.

• Authors: Maryam Azizian, Elahe Mahdipour, Seyed Reza Mirhafez, Sara Shoeibi, Mohsen Nematy, Habibollah Esmaily, Gordon Aa Ferns, Majid Ghayour-Mobarhan
• Journal: Annals of clinical biochemistry (Ann Clin Biochem) Vol. 53 Issue 6 Pg. 663-668 (Nov 2016) ISSN: 1758-1001 [Electronic] England
• PMID: 26787627 (Publication Type: Journal Article)

Chemical References

• CCL2 protein, human
• Chemokine CCL2
• IFNG protein, human
• Interleukins
• Tumor Necrosis Factor-alpha
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Epidermal Growth Factor
• Interferon-gamma
• C-Reactive Protein

Topics

• Adipose Tissue (metabolism, pathology)
• Adult
• Body Mass Index
• C-Reactive Protein (genetics, metabolism)
• Case-Control Studies
• Chemokine CCL2 (blood, genetics)
• Epidermal Growth Factor (blood, genetics)
• Female
• Gene Expression
• Humans
• Insulin Resistance
• Interferon-gamma (blood, genetics)
• Interleukins (blood, genetics)
• Male
• Middle Aged
• Obesity (blood, diagnosis, pathology)
• Tumor Necrosis Factor-alpha (blood, genetics)
• Vascular Endothelial Growth Factor A (blood, genetics)
• Waist Circumference