Abstract |
Chronic obstructive pulmonary disease ( COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress (OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers ( TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and lung function tests were measured in patients with mild stable asthma (n = 24) and mild stable COPD (n = 29) and in age- and sex-matched controls. Forced expiratory volume in 1 s (FEV1 ) was associated with age both in patients and control groups. By contrast, FEV1 was positively correlated with PSH only in COPD (ρ = 0·49, P = 0·007). In multiple logistic regression analysis, lower PSH was the only OS marker independently associated with increased odds of both asthma (OR = 0·32, 95% CI 0·13-0·78, P = 0·01) and COPD (OR = 0·50, 95% CI 0·26-0·95, P = 0·03). These findings suggest that proteins -SH are a sensitive OS marker in early COPD and asthma.
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Authors | Angelo Zinellu, Alessandro Giuseppe Fois, Salvatore Sotgia, Elisabetta Zinellu, Fabiana Bifulco, Gianfranco Pintus, Arduino A Mangoni, Ciriaco Carru, Pietro Pirina |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 46
Issue 2
Pg. 181-8
(Feb 2016)
ISSN: 1365-2362 [Electronic] England |
PMID | 26681451
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Stichting European Society for Clinical Investigation Journal Foundation. |
Chemical References |
- Biomarkers
- Sulfhydryl Compounds
- Thiobarbituric Acid Reactive Substances
- Taurine
- Ergothioneine
- Aryldialkylphosphatase
- PON1 protein, human
- Glutathione
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aryldialkylphosphatase
(metabolism)
- Asthma
(metabolism, physiopathology)
- Biomarkers
- Ergothioneine
(metabolism)
- Female
- Forced Expiratory Volume
- Glutathione
(metabolism)
- Humans
- Logistic Models
- Male
- Middle Aged
- Oxidative Stress
- Pulmonary Disease, Chronic Obstructive
(metabolism, physiopathology)
- Respiratory Function Tests
- Sulfhydryl Compounds
(metabolism)
- Taurine
(metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Vital Capacity
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