Abstract | BACKGROUND: METHODS: The HRCT scans of 162 patients with a histopathologic diagnosis of UIP or fibrotic NSIP (n = 162) were scored on extent of groundglass opacification, reticulation, honeycombing, emphysema and severity of traction bronchiectasis. For each patient, a fibroblastic foci profusion score based on histopathologic appearances was assigned. Relationships between extent of fibroblastic foci and individual HRCT patterns were investigated using univariate correlation analysis and multivariate linear regression. RESULTS: Increasing extent of reticulation (P < 0.0001) and increasing severity of traction bronchiectasis (P < 0.0001) were independently associated with increasing FF score within the entire cohort. Within individual multidisciplinary team diagnosis subgroups, the only significant independent association with FF score was severity of traction bronchiectasis in patients with idiopathic pulmonary fibrosis (IPF)/UIP (n = 66, r(2) = 0.19, P < 0.0001) and patients with chronic hypersensitivity pneumonitis (CHP) (n = 49, r(2) = 0.45, P < 0.0001). Furthermore, FF score had the strongest association with severity of traction bronchiectasis in patients with IPF (r(2) = 0.34, P < 0.0001) and CHP (r(2) = 0.35, P < 0.0001). There was no correlation between FF score and severity of traction bronchiectasis in patients with fibrotic NSIP. Global disease extent had the strongest association with severity of traction bronchiectasis in patients with fibrotic NSIP (r(2) = 0.58, P < 0.0001). CONCLUSION:
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Authors | Simon L F Walsh, Athol U Wells, Nicola Sverzellati, Anand Devaraj, Jan von der Thüsen, Samuel A Yousem, Thomas V Colby, Andrew G Nicholson, David M Hansell |
Journal | BMC medicine
(BMC Med)
Vol. 13
Pg. 241
(Sep 24 2015)
ISSN: 1741-7015 [Electronic] England |
PMID | 26399508
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Female
- Humans
- Lung Diseases
(diagnostic imaging, mortality, pathology)
- Lung Diseases, Interstitial
(diagnostic imaging, mortality, pathology)
- Male
- Middle Aged
- Survival Analysis
- Tomography, X-Ray Computed
(methods)
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