Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)

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746 relevant articles (18 outcomes, 65 trials/studies) found for this Disease

Description: A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.

Also Known As:

Hypersensitivity Pneumonitis; Alveolitis, Extrinsic Allergic; Allergic Alveolitides, Extrinsic; Alveolitides, Extrinsic Allergic; Extrinsic Allergic Alveolitides; Hypersensitivity Pneumonitides; Pneumonitides, Hypersensitivity; Allergic Alveolitis, Extrinsic; Pneumonitis, Hypersensitivity

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 377

Lung Diseases: 8942

Interstitial Lung Diseases: 2904

Extrinsic Allergic Alveolitis: 746

Farmer's Lung: 224

Bird Fancier's Lung: 61

Silo Filler's Disease: 9

Respiratory Hypersensitivity: 51

Extrinsic Allergic Alveolitis: 746

Farmer's Lung: 224

Bird Fancier's Lung: 61

Immune System Diseases: 1319

Hypersensitivity: 37871

Immediate Hypersensitivity: 1282

Respiratory Hypersensitivity: 51

Extrinsic Allergic Alveolitis: 746

Farmer's Lung: 224

Bird Fancier's Lung: 61

Related Diseases

1.	Sarcoidosis (Schaumann Disease)
2.	Tuberculosis
3.	Neoplasms (Cancer)
4.	Connective Tissue Diseases (Connective Tissue Disease)
5.	Idiopathic Pulmonary Fibrosis

Experts

1.	Costabel, Ulrich: 4 articles (01/2005 - 02/2004)
2.	Guzman, Josune: 4 articles (01/2005 - 02/2004)
3.	Yoshizawa, Yasuyuki: 3 articles (02/2007 - 04/2003)
4.	Chen, Baomin: 3 articles (01/2005 - 02/2004)
5.	Selman, Moisés: 2 articles (04/2008 - 02/2002)
6.	Martínez-Cordero, Erasmo: 2 articles (08/2007 - 01/2007)
7.	Retana, Virginia Novelo: 2 articles (08/2007 - 01/2007)
8.	Reboux, G: 2 articles (04/2007 - 02/2003)
9.	Dalphin, J-C: 2 articles (04/2007 - 02/2003)
10.	Ohtani, Yoshio: 2 articles (02/2007 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Extrinsic Allergic Alveolitis:

1.	AntigensIBA 11/01/1990 - "The measurement of rate of clearance of 99mTc-DTPA in pigeon fanciers can identify an alteration in pulmonary integrity more subtle than found with conventional pulmonary function tests and may therefore be a useful test for studying the pulmonary response to inhaled antigen and for detecting the earliest stages in the evolution of hypersensitivity pneumonitis." 01/15/1989 - "We report that electrostatic dust filters may be an effective treatment for patients with hypersensitivity pneumonitis when avoidance of the causative antigen cannot be easily and rapidly achieved." 10/01/2009 - "A provocation test, in which antigen exposure is limited using a closed space, such as a sickroom, was simple, safe and effective for determining the antigen causing hypersensitivity pneumonitis." 08/01/2007 - "We propose that the study of pigeon antigen by immunohistochemistry may be used as part of the diagnostic approach for hypersensitivity pneumonitis." 08/01/2007 - "Although the disease manifestations were compatible with hypersensitivity pneumonitis, we decided to study the causal antigen by immunohistochemistry. " Order ALL the reference details at left...
2.	PrecipitinsIBA 01/15/1989 - "The results of a bronchial challenge to Aspergillus species, however, remained positive; these positive results suggest that long-term memory immune mechanisms may play an important role in the pathogenesis of hypersensitivity pneumonitis and lessen the importance of precipitins in establishing a diagnosis. " 01/01/1980 - "A study was made of the prevalence of serum precipitins to Micropolyspora faeni, Thermoactinomyces vulgaris, Aspergillus fumigatus, and pigeon serum in population groups suspected to be at high risk for the development of hypersensitivity pneumonitis. " 04/01/2007 - "Serum precipitins have a controversial diagnostic value in hypersensitivity pneumonitis (HP). " 02/01/2003 - "[Hypersensitivity pneumonitis: a technical note on precipitins]" 07/01/1998 - "Hypersensitivity pneumonitis affected seven workers, with six exhibiting serum precipitins to Acinetobacter Iwoffii. " Order ALL the reference details at left...
3.	Immunoglobulin G (IgG)IBA 03/15/2006 - "In addition, the adoptive transfer of DTA-1-pretreated NKT cells into CD1d(-/-) mice attenuated hypersensitivity pneumonitis more than control IgG pretreated NKT cells in these mice. " 01/01/2005 - "OBJECTIVE: Determination of risk factors in the working environment that could explain the sensitisation process, and assessment of the differences in specific IgG levels to Aspergillus fumigatus, Saccharopolyspora rectivirgula and Thermoactynomices vulgaris in patients with hypersensitivity pneumonitis induced by esparto, exposed healthy plasterers and control population. " 01/01/2005 - "Specific IgG to Thermoactynomices vulgaris, Micropolyspora faeni and Aspergillus fumigatus in building workers exposed to esparto grass (plasterers) and in patients with esparto-induced hypersensitivity pneumonitis." 05/01/2004 - "Detection of IgG to specific fungi has been used as a marker of exposure to agents that may cause illnesses such as hypersensitivity pneumonitis. " 02/01/1998 - "A strong, dose-dependent inhibition of Rhodotorula IgG-ELISA by humidifier water was observed, suggesting that Rhodotorula might be the cause of hypersensitivity pneumonitis in this patient." Order ALL the reference details at left...
4.	AerosolsIBA 05/01/2006 - "Because hypersensitivity pneumonitis is not typically associated with exposure to metalworking fluid aerosols, this study examined whether Mycobacterium immunogenum (M. " 11/01/2003 - "Mycobacteria and pseudomonads occurring in modern metalworking fluids (MWF) have been implicated in occupational health hazards as causal agents for hypersensitivity pneumonitis (HP) and other respiratory illnesses in machine workers exposed to these fluids and their aerosols. " 11/01/2003 - "Recent outbreaks of hypersensitivity pneumonitis (HP) have been associated with exposures to metalworking (MWF) fluid aerosols. " 03/01/1997 - "Hypersensitivity pneumonitis to inhaled aerosols has been described; these aerosols are from several sources of water. " 09/01/1995 - "A hypersensitivity pneumonitis disorder associated with exposure to metalworking fluid aerosols." Order ALL the reference details at left...
5.	Immunoglobulins (Immunoglobulin)IBA 08/01/1993 - "The aim of this study was to investigate whether there is a relationship between the presence of plasma cells and other cells, and immunoglobulin levels in BAL fluid of patients with extrinsic allergic alveolitis. " 08/01/1993 - "RESULTS--Patients suffering from extrinsic allergic alveolitis with plasma cells in the BAL fluid (n = 18) had increased absolute numbers of lymphocytes, eosinophils and mast cells, a decreased percentage of alveolar macrophages and lower CD4/CD8 ratio, as well as higher immunoglobulin levels, when compared with patients with extrinsic allergic alveolitis having no plasma cells in the BAL fluid (n = 12). " 01/01/1978 - "Experimental hypersensitivity pneumonitis: serum immunoglobulins G1, G2, M, A and E in Micropolysopra faeni sensitized and desensitized calves." 10/01/1993 - "The aim of the present study was to investigate whether bronchoalveolar lavage (BAL) cell profile and immunoglobulin levels from patients with extrinsic allergic alveolitis (EAA) were related to the time elapsed between last antigen exposure and BAL. " 07/01/1999 - "Mucosal immunity in extrinsic allergic alveolitis: salivary immunoglobulins and antibody against inhaled avian antigens among pigeon breeders." Order ALL the reference details at left...
6.	Ribosomal DNA (rDNA)IBA 07/01/2001 - "Random amplified ribosomal DNA restriction analysis for rapid identification of thermophilic Actinomycete-like bacteria involved in hypersensitivity pneumonitis." 01/01/1997 - "We determined the partial sequences of large subunit rDNA of a new yeast species, Trichosporon domesticum, which was isolated from the house of a summer-type hypersensitivity pneumonitis patient. " 12/01/2002 - "Mushroom worker's lung (MWL) is a hypersensitivity pneumonitis or allergic alveolitis caused by a type III IgG-mediated immunopathogenic inflammatory reaction in the host due to the inhalation of several thermophilic organisms, including Thermoactinomyces spp. It is difficult to distinguish phenotypically the eight species of this genus; therefore, this study sought to develop an improved molecular means of identifying Thermoactinomyces spp. associated with MWL by partial 16S rDNA PCR amplification and direct sequencing. " Order ALL the reference details at left...
7.	SteroidsIBA 01/01/1977 - "In view of the observation that even in a steroid sensitive species like the rabbit, extensive pulmonary changes like alveolar consolidation, septal thickening and vasculitis persisted in spite of treatment with relatively large doses of these steroids, it was felt that in human hypersensitivity pneumonitis steroids might only suppress the warning symptoms without substantially affecting the progress of the pulmonary lesions." 02/01/2009 - "We diagnosed summer type hypersensitivity pneumonitis and this condition improved in response to antigen isolation and steroids. " 01/01/1977 - "To study the effects of steroids on the pulmonary lesions in experimental hypersensitivity pneumonitis, rabbits were sensitized to ovalbumin (OA) by injections of OA into footpads and 3 weeks later they were subjected to two successive aerosol challenges with OA at an interval of 48 hr. Injections of hydrocortisone sodium succinate 10 mg twice daily (but not at the reduced dosage of 5 mg twice daily) or methyprenisolone acetate 5 mg twice daily beginning 30 min before the first challenge and continued to the time of killing reduced the extent and intensity of vasculitis in both the treated groups and showed less alveolar septal thickening in the hydrocortisone treated group and less alveolar consolidation in the methylprednisolone treated group compared to the pulmonary lesions in the rabbits which were sensitized and then subjected to OA aerosol challenges, but received no treatment. " Order ALL the reference details at left...
8.	GlucocorticoidsIBA 01/01/1977 - "A study of the effects of systemic administration of adrenal glucocorticoids in an experimental model of hypersensitivity pneumonitis." 01/26/1984 - "Main indications of glucocorticoids are those conditions in which immunologic and/or inflammatory reactions have a deleterious effect: in asthma, combined with bronchodilators, glucocorticoids are the mainspring of management of severe attacks and protracted, severe asthma; corticosteroid aerosols have the advantage that systemic corticosteroid therapy can be avoided or shortened, thereby lessening the risk/benefit ratio; extrinsic allergic alveolitis, sarcoidosis with multiple localizations, and/or respiratory impairment, and protracted pulmonary eosinophilia, are choice indications for systemic corticosteroid therapy; glucocorticoids may be insufficiently effective in idiopathic pulmonary fibrosis or respiratory localizations of vasculitis, which may justify association of immunosuppressants; indications of glucocorticoids in certain forms of tuberculosis or cancer of the respiratory tract are less clearly systematized.(ABSTRACT TRUNCATED AT 250 WORDS)" Order ALL the reference details at left...
9.	Pentetic Acid (DTPA)FDA LinkGeneric 07/01/1990 - "Transfer of 99mTc DTPA and bronchoalveolar lavage findings in patients with asymptomatic extrinsic allergic alveolitis." 07/01/1990 - "Pulmonary clearance of inhaled technetium-99m labelled diethylene triamine penta-acetic acid (DTPA) was measured in seven patients with a history of extrinsic allergic alveolitis but with no symptoms at the time of the study and in 12 control subjects. " 12/01/2003 - "Chronic hypersensitivity pneumonitis with heart involvement observed during in-111 DTPA octreotide (OctreoScan) imaging." Order ALL the reference details at left...
10.	Acetic Acid (Vinegar)FDA LinkGeneric 07/01/1990 - "Pulmonary clearance of inhaled technetium-99m labelled diethylene triamine penta-acetic acid (DTPA) was measured in seven patients with a history of extrinsic allergic alveolitis but with no symptoms at the time of the study and in 12 control subjects. " Order ALL the reference details at left...

Therapies and Procedures

1.	Injections 09/01/1991 - "To establish a model of experimental hypersensitivity pneumonitis (EHP) in mice and to examine the influence of genetic background on the pulmonary inflammatory response to Micropolyspora faeni, we determined the responses of C57BL/6, SJL/J, and C3H/HeJ mice to intratracheal (i.t.) injections of M. " 10/01/1985 - "Pulmonary histologic abnormalities resolve despite continuing intratracheal injections of Micropolyspora faeni in a rabbit model of hypersensitivity pneumonitis. " 01/01/1977 - "Experimental hypersensitivity pneumonitis: reduced severity of clinical response following repeated injections of Micropolyspora faeni antigen." 01/01/1977 - "To study the effects of steroids on the pulmonary lesions in experimental hypersensitivity pneumonitis, rabbits were sensitized to ovalbumin (OA) by injections of OA into footpads and 3 weeks later they were subjected to two successive aerosol challenges with OA at an interval of 48 hr. Injections of hydrocortisone sodium succinate 10 mg twice daily (but not at the reduced dosage of 5 mg twice daily) or methyprenisolone acetate 5 mg twice daily beginning 30 min before the first challenge and continued to the time of killing reduced the extent and intensity of vasculitis in both the treated groups and showed less alveolar septal thickening in the hydrocortisone treated group and less alveolar consolidation in the methylprednisolone treated group compared to the pulmonary lesions in the rabbits which were sensitized and then subjected to OA aerosol challenges, but received no treatment. " Order ALL the reference details at left...
2.	Mechanical Ventilators (Ventilator) 12/01/1981 - "We conclude that respirators of this type can offer substantial, and in most cases complete, protection against single exposures to environmental dusts that may provoke extrinsic allergic alveolitis." 12/01/1981 - "Protective value of dust respirators in extrinsic allergic alveolitis: clinical assessment using inhalation provocation tests." Order ALL the reference details at left...
3.	Nebulizers and Vaporizers (Inhaler) 07/01/1989 - "Hypersensitivity pneumonitis by a cool-mist vaporizer: a detailed microbiologic and immunologic study." 07/01/1989 - "A patient with hypersensitivity pneumonitis caused by a contaminated cool-mist vaporizer was evaluated. " 04/01/1974 - "Hypersensitivity pneumonitis caused by a contaminated cool-mist vaporizer." Order ALL the reference details at left...
4.	Steam Bath (Sauna) 11/08/1976 - "Hypersensitivity pneumonitis due to contaminated water in a home sauna." Order ALL the reference details at left...
5.	Bronchoscopes 12/18/1987 - "The combination of BAL and transbronchial lung biopsies using modern flexible fiberoptic bronchoscopes allows the subdivision of lymphocytic alveolitis into sarcoidosis, exogenic allergic alveolitis (synonym: hypersensitivity pneumonitis: EAA) and granulomatous pneumonias caused by infectious agents. " Order ALL the reference details at left...

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