Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review.

Abstract

Obese subjects are often characterized by low plasma 25-hydroxy-vitamin D (25OHD) levels. Many explanations for this association have been proposed. Low plasma 25OHD is associated with obesity-related comorbidities such as insulin resistance, type 2 diabetes mellitus, and low-grade inflammation. In this review, we discuss the proposed mechanisms for low 25OHD in obesity and explore the results of recent RCTs on vitamin D (VD) supplementation on obesity and its metabolic complications such as insulin resistance and type 2 diabetes. Although the results from these clinical randomized controlled trials vary, the general picture is that VD treatment of obese individuals does not seem to be an effective treatment of obesity-related metabolic complications.

• Authors: Louise Wamberg, Steen B Pedersen, Lars Rejnmark, Bjørn Richelsen
• Journal: Current obesity reports (Curr Obes Rep) Vol. 4 Issue 4 Pg. 429-40 (Dec 2015) ISSN: 2162-4968 [Electronic] United States
• PMID: 26353882 (Publication Type: Journal Article, Review)

Chemical References

• Vitamins
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adipose Tissue
• Diabetes Mellitus, Type 2 (blood, drug therapy, etiology)
• Dietary Supplements
• Humans
• Inflammation
• Insulin Resistance
• Obesity (blood, complications, drug therapy)
• Risk Factors
• Vitamin D (analogs & derivatives, therapeutic use)
• Vitamin D Deficiency (blood, drug therapy, etiology)
• Vitamins (therapeutic use)