Abstract | OBJECTIVE: DESIGN AND METHODS: Data from 2893 participants of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study (Germany) was investigated through regression analysis. The results were adjusted for socio-demographic, life-style, and obesity measures as well as metabolic, inflammatory, and other iron biomarkers following a step-wise approach. Non-linearity was tested by adding a non-linear spline component to the model. RESULTS:
Ferritin and transferrin were positively associated with IGM (fourth vs first sex-specific quartile: ferritin odds ratio (OR)=2.08 (95% CI 1.43-3.04) and transferrin OR=1.89 (95% CI 1.32-2.70)), T2DM ( ferritin OR=1.98 (95% CI 1.22-3.22) and transferrin OR=2.42 (95% CI 1.54-3.81)), and fasting as well as 2-h glucose. TSAT (OR=0.55 (95% CI 0.34-0.88)) and iron (OR=0.61 (95% CI 0.38-0.97)) were inversely associated with T2DM, sTfR-F-index was inversely associated with IGM (OR=0.67 (95% CI 0.48-0.95)). There was no strong evidence for non-linear relationships. CONCLUSIONS: The observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM. Moreover, TSAT levels are decreased in T2DM patients.
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Authors | Cornelia Huth, Simon Beuerle, Astrid Zierer, Margit Heier, Christian Herder, Thorsten Kaiser, Wolfgang Koenig, Florian Kronenberg, Konrad Oexle, Wolfgang Rathmann, Michael Roden, Sigrid Schwab, Jochen Seissler, Doris Stöckl, Christa Meisinger, Annette Peters, Barbara Thorand |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 173
Issue 5
Pg. 643-53
(Nov 2015)
ISSN: 1479-683X [Electronic] England |
PMID | 26294793
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 European Society of Endocrinology. |
Chemical References |
- Biomarkers
- Blood Glucose
- Receptors, Transferrin
- Transferrin
- Ferritins
- Iron
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Topics |
- Adult
- Aged
- Biomarkers
(blood, metabolism)
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(blood, epidemiology, metabolism)
- Female
- Ferritins
(blood, metabolism)
- Germany
(epidemiology)
- Humans
- Iron
(blood, metabolism)
- Male
- Middle Aged
- Receptors, Transferrin
(blood, metabolism)
- Transferrin
(metabolism)
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