Abstract | BACKGROUND: METHODS: Retrospective study on 7 patients (5 women, 2 men) aged 57±14 years with pure TSH (n=4) or mixed TSH/GH (n=3) secreting pituitary adenomas primarily treated with first generation somatostatin analogs. Magnetic resonance imaging revealed a microadenoma in 3 patients and a macroadenoma in 4 patients. The follow-up period was 8.5±7.3 years. RESULTS: At initial diagnosis, the patients presented with thyrotoxicosis with elevated free thyroxine (26.5±6.5 pg/mL) and free triiodothyronine (7.3±0.9 pg/mL) levels and a mean TSH of 4.3±1.4 mU/L. During somatostatin analog treatment, free thyroid hormones and TSH levels normalized after 4.4±3.9 and 7.0±8.4 months, respectively. At the time of the last visit, 6 patients were biochemically controlled. Adenoma volume decreased in 6 patients and a decrease in adenoma volume persisted in 2 patients several years after initiation of somatostatin analog treatment. Safety of treatment was good and no patients discontinued somatostatin analogs due to side effects. CONCLUSION: This study confirms the efficacy of primary medical treatment with first-generation somatostatin analogs in terms of hormonal control and tumor volume reduction in patients with TSH-secreting pituitary adenomas, and its good safety profile. First-generation somatostatin analogs may serve as a medical alternative to surgical treatment, especially in patients where surgery is contraindicated or in subjects presenting with invasive macroadenomas that render complete surgical resection difficult.
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Authors | Frédérique Rimareix, Solange Grunenwald, Delphine Vezzosi, Louis-David Rivière, Antoine Bennet, Philippe Caron |
Journal | Thyroid : official journal of the American Thyroid Association
(Thyroid)
Vol. 25
Issue 8
Pg. 877-82
(Aug 2015)
ISSN: 1557-9077 [Electronic] United States |
PMID | 26244412
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Triiodothyronine
- Somatostatin
- Insulin-Like Growth Factor I
- Thyrotropin
- Growth Hormone
- Thyroxine
- Octreotide
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Topics |
- Adenoma
(metabolism, pathology, surgery)
- Adult
- Aged
- Female
- Follow-Up Studies
- Growth Hormone
(blood)
- Humans
- Injections, Intramuscular
- Insulin-Like Growth Factor I
(metabolism)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Octreotide
(therapeutic use)
- Pituitary Neoplasms
(metabolism, pathology, surgery)
- Retrospective Studies
- Somatostatin
(analogs & derivatives, therapeutic use)
- Thyrotropin
(metabolism)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
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