Pituitary Neoplasms (Pituitary Adenoma)

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4939 relevant articles (141 outcomes, 569 trials/studies) found for this Disease

Description: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.

Also Known As:

Pituitary Adenoma; Pituitary Tumors; Pituitary Tumor; Cancer of Pituitary; Cancer of the Pituitary; Pituitary Carcinoma; Adenoma, Pituitary; Adenomas, Pituitary; Cancer, Pituitary; Cancers, Pituitary; Carcinoma, Pituitary; Carcinomas, Pituitary; Neoplasm, Pituitary; Neoplasms, Pituitary; Pituitary Adenomas; Pituitary Cancers; Pituitary Carcinomas; Pituitary Neoplasm; Tumor, Pituitary; Tumors, Pituitary; Pituitary Cancer

Relationship Network

Disease Context: Research Results

Neoplasms: 415397

Neoplasms by Site: 1

Nervous System Neoplasms: 146

Central Nervous System Neoplasms: 261

Brain Neoplasms: 6947

Supratentorial Neoplasms: 52

Hypothalamic Neoplasms: 31

Pituitary Neoplasms: 4939

Endocrine Gland Neoplasms: 37

Pituitary Neoplasms: 4939

Prolactinoma: 1619

Growth Hormone-Secreting Pituitary Adenoma: 228

ACTH-Secreting Pituitary Adenoma: 213

Endocrine System Diseases: 398

Pituitary Diseases: 334

Pituitary Neoplasms: 4939

Prolactinoma: 1619

Growth Hormone-Secreting Pituitary Adenoma: 228

ACTH-Secreting Pituitary Adenoma: 213

Endocrine Gland Neoplasms: 37

Pituitary Neoplasms: 4939

Prolactinoma: 1619

Growth Hormone-Secreting Pituitary Adenoma: 228

ACTH-Secreting Pituitary Adenoma: 213

Related Diseases

1.	Neoplasms (Cancer)
2.	Acromegaly
3.	Adenoma (Adenomas)
4.	Prolactinoma (Prolactinomas)
5.	Hyperthyroidism

Experts

1.	Teramoto, Akira: 10 articles (09/2008 - 10/2002)
2.	Kovacs, Kalman: 10 articles (02/2008 - 05/2003)
3.	Pawlikowski, Marek: 9 articles (01/2006 - 10/2002)
4.	Colao, Annamaria: 8 articles (03/2008 - 06/2002)
5.	Yamada, Shozo: 8 articles (01/2008 - 06/2003)
6.	Lloyd, Ricardo V: 8 articles (06/2006 - 01/2003)
7.	Lombardi, Gaetano: 7 articles (03/2008 - 06/2002)
8.	Scheithauer, Bernd W: 7 articles (02/2008 - 05/2003)
9.	Grossman, A B: 7 articles (01/2006 - 01/2001)
10.	Teramoto, A: 7 articles (09/2001 - 08/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pituitary Neoplasms:

1.	HormonesIBA 06/01/2009 - "Radiotherapy (RT) remains an effective treatment for residual or recurrent pituitary adenomas with excellent rates of tumour control and normalisation of excess hormone secretion. " 12/01/2005 - "The development of animal models for pituitary tumors and hormone hypersecretion has proven to be critical for the implementation of novel treatment strategies and gene therapy approaches. " 06/01/1997 - "Following transsphenoidal removal of the pituitary tumor and appropriate hormone replacement, complete remission of the skin disorder was obtained. " 05/01/2006 - "CONCLUSION: SCRT as a high-precision technique of localized irradiation achieves tumour and hormone control of pituitary adenomas comparable with previously published data on the efficacy of conventional radiotherapy. " 02/15/1997 - "SRIF analogs with selective affinity for this receptor may therefore be more effective in the treatment of hormone-secreting pituitary adenomas." Order ALL the reference details at left...
2.	Octreotide (Sandostatin)FDA LinkGeneric 01/01/2007 - "CONCLUSION: DCE-MRI in acromegalic tumours treated with octreotide showed a significant reduction in functional vascularity after octreotide therapy compared to baseline in pituitary adenomas. " 11/01/1988 - "Thus, preoperative administration of SMS 201-995 consistently induced shrinkage of GH-producing pituitary tumors, and the apparent remission rate was high in the treated patients." 12/01/2005 - "Octreotide LAR could be used as primary therapy in patients harbouring large pituitary tumors, who are less likely to be cured by neurosurgery." 04/17/1995 - "In this study, the apoptotic effect of the octreotide SS analog, SMS 201-995, was investigated in phase synchronized AtT-20 mouse pituitary tumor cells. " 11/01/1992 - "Clinically nonfunctioning pituitary adenoma and octreotide response to long term high dose treatment, and studies in vitro." Order ALL the reference details at left...
3.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 08/01/2006 - "OBJECTIVES: Somatostatin (SST) analogues play an important role in the medical management of somatotroph pituitary adenomas and new agonists have the potential to be effective in a wider group of pituitary and other tumours. " 04/01/2003 - "This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease." 01/01/1993 - "In patients with visual disturbances related to chiasmal compression by nonfunctioning pituitary tumors, somatostatin analog administration has been reported to result in rapid improvement in visual acuity. " 04/01/2000 - "Somatostatin analogs have been shown to be effective for the treatment of TSH-secreting pituitary adenomas. " 08/01/2006 - "These cases illustrate that long-term treatment with somatostatin analogs offers an alternative choice in selected acromegalic patients, such as those with pituitary tumor who cannot be cured by surgery, those who have unacceptable anesthetic risk and those who refuse surgery." Order ALL the reference details at left...
4.	Bromocriptine (Parlodel)FDA LinkGeneric 12/01/1986 - "Rapid improvement in visual field defects following bromocriptine treatment of patients with non-functioning pituitary adenomas." 03/01/1982 - "Bromocriptine causes a clinically significant reduction in size of nonsecreting as well as secreting pituitary tumors with the same success rate as that of conventional treatments.U" 04/01/2002 - "Although medical treatment with bromocriptine is effective for patients with pituitary adenomas, little is known about the molecular mechanisms of gene regulation mediated by D2 receptors. " 01/01/1995 - "Conventional therapy with transsphenoidal surgery, external-beam radiotherapy, and bromocriptine has enabled the majority of patients with pituitary tumors to be effectively treated. " 02/01/1989 - "Although it is well known that bromocriptine (BC) is effective in the treatment of functioning pituitary adenoma, this agent sometimes causes severe gastrointestinal side effects. " Order ALL the reference details at left...
5.	Adrenocorticotropic Hormone (ACTH)FDA Link 02/01/2001 - "In all 14 Cushing's disease patients (cured and not cured), mean plasma ACTH levels were significantly greater 10 min after pituitary tumor resection (54.4+/-12.8 pmol/l) than in the premanipulation period (ACTH=26.3+/-5.3 pmol/l) (p=0.005). " 04/01/2003 - "Spoiled gradient recalled acquisition in the steady state technique is superior to conventional postcontrast spin echo technique for magnetic resonance imaging detection of adrenocorticotropin-secreting pituitary tumors." 08/01/2001 - "CONCLUSION: Stereotactic radiosurgery is a safe and effective method in the treatment of patients with adrenocorticotropic hormone-producing pituitary tumors, and the effect of treatment is long-lasting. " 07/01/2002 - "Pituitary tumor stained for adrenocorticotropic hormone was detected in 78% of resected pituitary tissue specimens obtained from patients who achieved remission, compared with 53% from patients who experienced surgical failure (P = 0.06). " 02/01/2001 - "ACTH level does not change in the early recovery period after ACTH-secreting pituitary tumor, even in those cured patients, and probably peri-tumoral normal corticotrophs are not completely suppressed by cronic hypercortisolemia (and acute glucocorticoid administration) when these patients are under intense stress, like transsphenoidal surgery. " Order ALL the reference details at left...
6.	Growth Hormone (Somatotropin)IBA 09/01/2001 - "Although it seems to be very effective in controlling growth and secretion of the growth hormone-secreting pituitary adenomas, there is a chance that some major risks from gamma knife radiosurgery might occur. " 05/01/2007 - "Radiosurgery of growth hormone-producing pituitary adenomas: factors associated with biochemical remission." 08/01/2007 - "CONCLUSIONS: This study reports on the unusual case of a patient with mild short stature, who acquired GHD in late adulthood due to a non-secreting pituitary adenoma and get additionally diagnosed for pre-existing growth hormone insensitivity due to a formerly in two short statured patients described, single, heterozygous, non-synonymous mutation in the GHR. " 07/01/1997 - "Endocrine studies indicated that her pituitary tumor was active with hyperproduction of growth hormone. " 08/01/1992 - "Immunohistology and explant culture studies documented growth hormone secreting pituitary adenomas in all cases. " Order ALL the reference details at left...
7.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 11/01/1990 - "Thyrotropin-secreting pituitary adenomas have been diagnosed more frequently as radiographic techniques and biochemical assays have improved; however, they remain uncommon and are unfamiliar to most neurosurgeons. " 08/01/2004 - "Pathological study of thyrotropin-secreting pituitary adenoma: plurihormonality and medical treatment." 11/15/1989 - "STUDY OBJECTIVE: To evaluate the clinical and biochemical features of patients with TSH (thyroid-stimulating hormone, thyrotropin)-secreting pituitary tumors; to measure the biologic activity in vitro of circulating TSH from selected patients before and after pituitary surgery. " 06/01/1989 - "Clinical and molecular studies of a thyrotropin-secreting pituitary adenoma." 01/01/2009 - "[Thyrotropin-secreting pituitary adenomas]" Order ALL the reference details at left...
8.	ProlactinIBA 06/01/1978 - "In spite of improved diagnosis and treatment, the natural history of prolactin-secreting pituitary tumors and the long-range effects are still not fully appreciated. " 03/01/2006 - "In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). " 12/01/1996 - "In this study, the effects of CsA on prolactin (PRL) synthesis and release were investigated in GH3 cells, a clonal strain of rat pituitary tumor. " 09/01/1995 - "Post-mortem studies confirmed the diagnosis of a metastasizing prolactin-secreting pituitary carcinoma. " 05/01/1995 - "Histological, immunocytochemical, and ultrastructural studies of the surgically removed tissue revealed a pleomorphic, chromophobic, or slightly acidophilic pituitary tumor that was immunoreactive for prolactin and that, according to electron microscopy, consisted of atypical lactotrophs showing no evidence of cell shrinkage. " Order ALL the reference details at left...
9.	Dopamine Agonists (Dopamine Agonist)IBA 01/01/2006 - "Can dopamine agonists prevent postoperative remnant enlargement in nonfunctioning pituitary adenomas?" 10/01/2005 - "Furthermore, dopamine agonists can also be used in other pituitary tumors. " 10/01/2005 - "Treatment of pituitary tumors: dopamine agonists." 07/01/2005 - "CONCLUSIONS: Dopamine agonist therapy is associated with a decreased prevalence of residual tumour enlargement in patients with nonfunctioning pituitary adenomas, particularly when treatment is instituted before tumour remnant growth is detected." 07/01/2005 - "Postoperative treatment of clinically nonfunctioning pituitary adenomas with dopamine agonists decreases tumour remnant growth." Order ALL the reference details at left...
10.	Insulin-Like Growth Factor I (IGF-1)IBA 01/01/2009 - "IGF-I gene therapy appears to be an effective approach for the treatment of experimental somatomammotropic pituitary tumors and could be potentially useful as an adjuvant of conventional therapies." 01/01/2009 - "The treatment of pituitary adenomas with RAd-IGF-I induced a significant (p < 0.05) decrease in cell size with respect to E(2) + RAd-GFP (51.3 +/- 0.3 vs. 58.9 +/- 0.3 microm(2)) and no changes in cell density compared with RAd-GFP-injected animals (12.8 +/- 1.7 vs. 10.5 +/- 0.1). " 05/01/2007 - "Patients with GH-producing pituitary adenomas should not undergo further radiation therapy or surgery for at least 5 years after radiosurgery because GH and IGF-I levels continue to normalize over that interval." 01/01/2007 - "Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development." 01/01/2006 - "Current definition of resistance to SS analogs is based on their efficacy to control GH and IGF-I. However, due to the emerging significance of the shrinkage effect of SS analogs on pituitary adenomas as well as to the apparent dissociation between this effect and the biochemical effects of treatment with these analogs, an evolution in the concept of SS resistance is likely to be occurring. " Order ALL the reference details at left...

Therapies and Procedures

1.	Hypophysectomy 12/01/1992 - "Of the 214 OSA patients who accepted CPAP, 181 are still on treatment, with a mean daily rate of use of 5.6 +/- 0.1 hours (mean +/- SEM); 22 patients stopped CPAP after a variable period of time; 10 patients died and one acromegalic patient was considered cured after hypophysectomy for a pituitary adenoma. " 08/01/1987 - "Only 7 of the 100 patients had no pituitary adenoma found at operation, and they obtained no clinical remission even after partial or subtotal hypophysectomy. " 12/22/2001 - "For the past few decades, hypophysectomy has been used for the treatment of pituitary adenomas in dogs and cats that are kept as pets." 10/01/2000 - "Patient #1; a 46 year old lady with Cushing's disease (CD) presented with an enlarged right cervical lymph node (LN) 2 years after having undergone a partial hypophysectomy through transsphenoidal surgery (PHYPX/TSS) and ERT for an invasive pituitary tumor. " 03/01/2000 - "During surgery, the surgeon identified and removed 17 pituitary tumors; 15 patients had selective adenomectomies, one had a hemihypophysectomy, and two had total hypophysectomies. " Order ALL the reference details at left...
2.	Decompression 07/01/2009 - "OBJECTIVE: This is the first report of the simultaneous combined use of trans-sphenoidal and trans-ventricular-endoscopic route for decompression of a giant pituitary adenoma. " 07/01/2009 - "Combined trans-sphenoidal and simultaneous trans-ventricular-endoscopic decompression of a giant pituitary adenoma: case report." 12/01/2008 - "These cases include minimally invasive cervical and lumbar decompression procedures, as well as more recently the resection of larger and more extensive pituitary tumors. " 08/01/2008 - "All four patients underwent transethmoidal decompression of the pituitary adenoma. " 08/01/2005 - "Furthermore, given the preoperative uncertainty about the suprasellar extension of pituitary tumors prior to modern neuroimaging, the transfrontal route assured Cushing an adequate decompression of the optic chiasm. " Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 12/01/1998 - "Until another more specific form of treatment is available, chemotherapy may still be of some value in patients with highly aggressive and malignant pituitary tumors, at least in achieving a temporary remission or delay in progression. " 10/01/2006 - "The authors report rare examples of a persistent response to cytotoxic chemotherapy in two patients with pituitary carcinoma. " 04/01/2005 - "[Capacities of chemotherapy for pituitary tumors]" 12/01/1998 - "The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors." 03/10/1991 - "[Drug therapy of pituitary tumors]" Order ALL the reference details at left...
4.	Photochemotherapy (Photodynamic Therapy) 08/01/2000 - "Effect of photodynamic therapy on recurrent pituitary adenomas: clinical phase I/II trial--an early report." 04/01/1998 - "A preliminary experimental in vivo study of the effect of photodynamic therapy on human pituitary adenoma implanted in mice." 01/01/1993 - "In vitro study of the effect of photodynamic therapy on pituitary adenomas." 07/01/1995 - "Adjuvant therapy for pituitary adenomas: the possible role of photodynamic therapy." 08/01/2004 - "METHODS: Eight patients (seven men) with recurrent pituitary adenomas who had undergone previous surgery and radiation therapy were recruited for a Phase I/II feasibility study of the application of photodynamic therapy to pituitary tumors. " Order ALL the reference details at left...
5.	Transplants (Transplant) 05/01/2005 - "Reconstruction of the sellar floor after pituitary tumor removal is sometimes difficult because the repair graft is difficult to handle in the narrow space. " 04/01/1992 - "A case of interposed nerve graft repair of an oculomotor nerve damaged during surgery for a laterally growing retrosellar pituitary adenoma is reported. " 01/01/1981 - "Subhypothalamic grafts of human pituitary adenomas in total-body irradiated rats." 01/15/1973 - "Fine structure of pituitary tumors and transplants in mice: effects on the prostate." 11/22/1952 - "[Pituitary tumor operated on by transmaxillo-sphenoid route with application of adipose grafts in the pituitary fossa.]" Order ALL the reference details at left...

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