Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC.
|
| Abstract | BACKGROUND:
Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung carcinoma cases, which becomes more and more important in the field of lung carcinoma as well as primary lung carcinoma in females. MATERIAL AND METHODS: We analyzed the medical history of 62 female NSCLC patients. Immunohistochemistry was used to observe and compare the expression of EGFR. The chi-square test was conducted to analyze associations between EGFR expression and the different variables. The cumulative survival rate was determined by the Kaplan-Meier product-limit method. The prognosis of female patients with NSCLC was examined by using a multivariate Cox proportional hazard regression model. RESULTS: The expression proportion of EGFR in Chinese female NSCLC patients was 70.97%, and it was remarkably higher in adenocarcinoma than in squamous cell carcinoma and bronchioloalveolar carcinoma. A positive correlation was observed between EGFR expression and tumor-node metastasis staging or lymph node metastasis. The Cox proportional risk model analysis showed a correlation between postoperative survival time of the patients and pathology of the tumor type and lymph node metastasis. CONCLUSIONS: Expression of EGFR was closely related to pathology of the tumor type, tumor-node metastasis staging, and lymph node metastasis, which could be used as a promising indicator of NSCLC in Chinese female patients.
|
|---|---|
| Authors | Guangyuan Sun, Bing Liu, Jin He, Xuewei Zhao, Bing Li |
| Journal | Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 21 Pg. 2225-31 (Jul 31 2015) ISSN: 1643-3750 [Electronic] United States |
| PMID | 26230859 (Publication Type: Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!